Results 61 to 70 of about 9,634,082 (235)

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library. [PDF]

PLoS ONE, 2017
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein
Manuela O Gustafsson, Dara K Mohammad, Erkko Ylösmäki, Hyunseok Choi, Subhash Shrestha, Qing Wang, Beston F Nore, Kalle Saksela, C I Edvard Smith   +8 more
doaj   +1 more source

Association between ankyrin 2 gene and breast cancer progression: A preliminary computational assessment using the database approach

Informatics in Medicine Unlocked, 2021
Breast cancer (BC) is considered the second leading cause of cancer-related death in women. Accurate diagnosis is thus of utmost importance to avoid the burden of BC.
Md. Roman Mogal, Md. Rashel Mahmod, Sagarika Adhikary Sompa, Asadullah Junayed, Md. Zainul Abedin, Md. Asaduzzaman Sikder   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Obscurin Targets Ankyrin-B and Protein Phosphatase 2A to the Cardiac M-line [PDF]

Journal of Biological Chemistry, 2008
Ankyrin-B targets ion channels and transporters in excitable cells. Dysfunction in ankyrin-B-based pathways results in defects in cardiac physiology. Despite a wealth of knowledge regarding the role of ankyrin-B for cardiac function, little is known regarding the mechanisms underlying ankyrin-B regulation.
Shane R, Cunha, Peter J, Mohler
openaire   +2 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

Burns & Trauma, 2018
Background The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown.
Peng-Ran Du, Hong-Ting Lu, Xi-Xiang Lin, Li-Feng Wang, Yan-Xia Wang, Xiao-Ming Gu, Xiao-Zhi Bai, Ke Tao, Jing-Jun Zhou   +8 more
doaj   +1 more source

Kinin B₂ and B₁ Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms

Pharmaceutics, 2023
Aromatase inhibitors (AIs) cause symptoms of musculoskeletal pain, and some mechanisms have been proposed to explain them. However, signaling pathways downstream from kinin B2 (B2R) and B1 (B1R) receptor activation and their possible sensitizing of the ...
Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Gabriela Becker, Indiara Brusco, Sara Marchesan Oliveira   +4 more
doaj   +1 more source

ImmunoEM of ankyrin B and G.

, 2016
Ankyrin B clusters at the lateral microvillar in-folding of distal tubule cells. Ankyrin G is present at the apical and lateral membrane (LM) and on cytoplasmic vesicles (arrow heads) and near the brush border of proximal tubule cells (arrows). The boxed
Michael C. Stankewich (842238), Thomas Ardito (842241), Lan Ji (842240), Gilbert W. Moeckel (842239), Jon S. Morrow (842242)   +4 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Kinin B₂ Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Pharmaceuticals, 2023
Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1 ...
Gabriela Becker, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Sara Marchesan Oliveira   +3 more
doaj   +1 more source