Results 81 to 90 of about 9,634,082 (235)

Model of the Cardiac Ankyrin-B Complex

, 2013
(Left) Model of ankyrin-B-dependent complex of NKA, NCX1, and InsP3R at T-tubule/SR sites distinct from the classic “dyad.” (Right) Scale model of ankyrin-B complex based on approximate dimensions of represented proteins. The protein ratios are
Vann Bennett (12418), Peter J Mohler (12416), Jonathan Q Davis (12417)   +2 more
core   +1 more source

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group [PDF]

, 2007
BACKGROUND: Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes ...
Parkhill Julian, Sinkins, Steven P., Thomson Nicholas R, Sanders, Mandy J, Klasson Lisa, Walker, T, Sanders, MJ, Sebaihia, M, Parkhill, J, Sinkins Steven P, Klasson, L, Sanders, Mandy J., Klasson, Lisa, Thompson, Nicholas R., Sinkins, Steven P, Sanders Mandy J, Sebaihia, Mohammed, Sebalhia, Mohammed, Parkhill, Julian, Walker, Thomas, Thomson, Nicholas R, Walker Thomas, Thomson, Nicholas R., Sinkins, SP, Sebaihia Mohammed, Thomson, NR   +25 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Comparisons in temperature and photoperiodic-dependent diapause induction between domestic and wild mulberry silkworms

Scientific Reports, 2021
The bivoltine strain of the domestic silkworm, Bombyx mori, has two generations per year. It shows a facultative diapause phenotype determined by environmental conditions, including photoperiod and temperature, and nutrient conditions during embryonic ...
Takeshi Yokoyama, Shigeru Saito, Misato Shimoda, Masakazu Kobayashi, Yoko Takasu, Hideki Sezutsu, Yoshiomi Kato, Makoto Tominaga, Akira Mizoguchi, Kunihiro Shiomi   +9 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Two Variants of the ANK1 Gene Associated with Hereditary Spherocytosis

Biomedicines
Background Hereditary spherocytosis (HS) is an erythrocytic membranopathy that belongs to a group of rare genetic disorders. Mutations in five genes, including ANK1, cause clinical manifestations of the disease.
Dżamila M. Bogusławska, Justyna Rybka, Paulina Koszela, Kazimierz Kuliczkowski, Aleksander F. Sikorski   +4 more
doaj   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

An Ankyrin-Based Mechanism for Functional Organization of Dystrophin and Dystroglycan

, 2008
Summaryβ-dystroglycan (DG) and the dystrophin-glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma of skeletal muscle.
Ayalon, Gai, Scotland, Paula B., Paula B. Scotland, Gai Ayalon, Davis, Jonathan Q., Jonathan Q. Davis, Vann Bennett, Bennett, Vann   +7 more
core   +1 more source