Results 91 to 100 of about 9,634,082 (235)
Journal of Clinical and Translational ScienceOBJECTIVES/GOALS: The cytoskeletal protein α²II spectrin interacts with actin and ankyrin-2 in cardiomyocytes which is essential to orchestrate ion channels and membrane proteins in the cardiac dyad.
Jyotsna Joshi +10 more
doaj +1 more source
Journal of Integrative Agriculture, 2016 The nuclear-encoded light-harvesting chlorophyll a/b-binding proteins (LHCPs) are specifically translocated from the stroma into the thylakoid membrane through the chloroplast signal recognition particle (cpSRP) pathway.
Zhong-wei WANG +12 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski +4 more
wiley +1 more source
ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis.
PLoS ONE, 2010 Arfs and Arf GTPase-activating proteins (ArfGAPs) are regulators of membrane trafficking and actin dynamics in mammalian cells. In this study, we identified a primordial Arf, ArfA, and two ArfGAPs (ACAP-A/B) containing BAR, PH, ArfGAP and Ankyrin repeat ...
Pei-Wen Chen +2 more
doaj +1 more source
MicroRNA‑34a mediates atrial fibrillation through regulation of Ankyrin‑B expression
Molecular Medicine Reports, 2018 Atrial fibrillation (AF) has a high prevalence and recurrence rate, and is associated with substantial mortality. However, its underlying mechanisms are not thoroughly understood. Increasing attention has been paid to the roles of microRNAs (miRs) in the pathogenesis of cardiovascular disease, including miR‑1 and miR‑133 (in the electrophysiological ...
Yun, Zhu +3 more
openaire +3 more sources
Insights into ANKRD11‐related epilepsy from 163 people
Epilepsia, EarlyView.Abstract Objective Ankyrin repeat domain 11 gene (ANKRD11) is the key disease gene for autosomal dominant KBG syndrome, and a subset of affected individuals develop epilepsy. However, comprehensive characterization of epilepsy‐related phenotypes and genotype–phenotype correlations in ANKRD11 variant carriers remains limited.
Song Su +6 more
wiley +1 more source
, 2012 Ankyrin-R/B/G (encoded by ANK1/2/3, respectively) are a family of very large scaffold proteins capable of anchoring numerous receptors and ion channels to specific, spectrin-containing membrane micro-domains. Hereditary mutations of ankyrins are known to
Wang, Chao +4 more
core +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
Mechanistic studies of ankyrin-B/ankyrin-G autoinhibition and regulation
, 2014 Ankyrins are a family of scaffold proteins, which serves to link great varieties of functional related but structurally diverse integral membrane proteins to the spectrin-based cytoskeletons.
Chen, Keyu
core
Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, EarlyView.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source