Results 31 to 40 of about 36,997 (223)
Developmental mechanism of the periodic membrane skeleton in axons
eLife, 2014 Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown.
Guisheng Zhong +6 more
doaj +1 more source
Cardiac ankyrins in health and disease [PDF]
Journal of Molecular and Cellular Cardiology, 2009 Ankyrins are critical components of ion channel and transporter signaling complexes in the cardiovascular system. Over the past 5 years, ankyrin dysfunction has been linked with abnormal ion channel and transporter membrane organization and fatal human arrhythmias.
Seyed M, Hashemi +2 more
openaire +2 more sources
A clinical and experimental study of adult hereditary spherocytosis in the Chinese population
Kaohsiung Journal of Medical Sciences, 2020 Hereditary spherocytosis (HS) is often misdiagnosed due to lack of specific diagnostic methods. Our study summarized clinical characteristics and described the diagnostic workflow for mild and moderate HS in Chinese individuals, using data from 20 adults,
Jun Xue +4 more
doaj +1 more source
Biomolecules, 2020 Ankyrin-B (encoded by ANK2), originally identified as a key cytoskeletal-associated protein in the brain, is highly expressed in the heart and plays critical roles in cardiac physiology and cell biology.
Holly C. Sucharski +5 more
doaj +1 more source
LQT4 Gene: The "Missing" Ankyrin [PDF]
Molecular Interventions, 2003 Mutations in ion channels have been implicated in the formation of long QT syndrome (LQTS). However, Mohler et al. have recently uncovered a role for ankyrin-B, a non-ion channel protein, in type IV LQTS. Calcium signalling is altered, and the functions of several channels and pumps that normally interact with wild-type ankyrin-B are impaired in the ...
Sandro, Yong, Xiaoli, Tian, Qing, Wang
openaire +2 more sources
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. [PDF]
PLoS Genetics, 2016 In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion ...
Timothy Jegla +9 more
doaj +1 more source
PLOS Genetics, 2021 The number of grains per panicle is an important yield-related trait in cereals which depends in part on panicle branching complexity. One component of this complexity is the number of secondary branches per panicle. Previously, a GWAS site associated with secondary branch and spikelet numbers per panicle in rice was identified.
Giang Ngan Khong +11 more
openaire +5 more sources
Defects in Cytoskeletal Signaling Pathways, Arrhythmia, and Sudden Cardiac Death
Frontiers in Physiology, 2012 Ankyrin polypeptides are cellular adapter proteins that tether integral membrane proteins to the cytoskeleton in a host of human organs. Initially identified as integral components of the cytoskeleton in erythrocytes, a recent explosion in ankyrin ...
Sakima A Smith +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
STORMing towards a clear picture of the cytoskeleton in neurons
eLife, 2015 Super-resolution microscopy has shed new light on the formation of the actin-spectrin network in neurons.
Emerson Stewart, Kang Shen
doaj +1 more source