Results 11 to 20 of about 36,997 (223)

Ankyrins [PDF]

FEBS Letters, 2000
This review is focused on ankyrin which is a protein linker between the integral membrane proteins and spectrin‐based cytoskeleton. Structure and distribution of different ankyrin isoforms that are products of alternative‐spliced genes are described. Interaction of ankyrins with various membranes is considered.
Rubtsov, Alexander M, Lopina, Olga D
openaire   +2 more sources

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

eLife, 2021
Variants in the high confident autism spectrum disorder (ASD) gene ANK2 target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms.
Blake A Creighton, Simone Afriyie, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos, Joan Reger, April M Burch, Eric Dyne, Julia Bay, Jeffrey K Huang, ES Anton, Meng-Meng Fu, Damaris N Lorenzo   +12 more
doaj   +1 more source

Severe hereditary spherocytosis presenting with non-immune fetal hydrops

Indian Pediatrics Case Reports, 2023
Background: Hereditary spherocytosis (HS) is characterized by spherocytes on the peripheral smear and heterogeneous clinical presentation (mild, moderate, moderate/severe, and severe) depending upon the severity of hemolytic anemia, jaundice, and ...
Snehal Mallakmir, Rashid Merchant, Nandkishor S Kabra, Javed Ahmed   +3 more
doaj   +1 more source

Evolutionary dissection of monkeypox virus: Positive Darwinian selection drives the adaptation of virus–host interaction proteins

Frontiers in Cellular and Infection Microbiology, 2023
The emerging and ongoing outbreak of human monkeypox (hMPX) in 2022 is a serious global threat. An understanding of the evolution of the monkeypox virus (MPXV) at the single-gene level may provide clues for exploring the unique aspects of the current ...
Xiao-Yong Zhan, Gao-Feng Zha, Yulong He
doaj   +1 more source

Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production

Biomolecules, 2021
Previously, a designed ankyrin repeat protein, AnkGAG1D4, was generated for intracellular targeting of the HIV-1 capsid domain. The efficiency was satisfactory in interfering with the HIV assembly process.
Kanokporn Sornsuwan, Weeraya Thongkhum, Thanathat Pamonsupornwichit, Tanawan Samleerat Carraway, Suthinee Soponpong, Supachai Sakkhachornphop, Chatchai Tayapiwatana, Umpa Yasamut   +7 more
doaj   +1 more source

Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes

Journal of Cardiovascular Development and Disease, 2021
The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart.
Drew Nassal, Jane Yu, Dennison Min, Cemantha Lane, Rebecca Shaheen, Daniel Gratz, Thomas J. Hund   +6 more
doaj   +1 more source

AtTPR10 Containing Multiple ANK and TPR Domains Exhibits Chaperone Activity and Heat-Shock Dependent Structural Switching

Applied Sciences, 2020
Among the several tetratricopeptide (TPR) repeat-containing proteins encoded by the Arabidopsis thaliana genome, AtTPR10 exhibits an atypical structure with three TPR domain repeats at the C-terminus in addition to seven ankyrin (ANK) domain repeats at ...
Seol Ki Paeng, Chang Ho Kang, Yong Hun Chi, Ho Byoung Chae, Eun Seon Lee, Joung Hun Park, Seong Dong Wi, Su Bin Bae, Kieu Anh Thi Phan, Sang Yeol Lee   +9 more
doaj   +1 more source

Mechanical Anisotropy of Ankyrin Repeats [PDF]

Biophysical Journal, 2012
Red blood cells are frequently deformed and their cytoskeletal proteins such as spectrin and ankyrin-R are repeatedly subjected to mechanical forces. While the mechanics of spectrin was thoroughly investigated in vitro and in vivo, little is known about the mechanical behavior of ankyrin-R.
Lee, W, Zeng, X, Rotolo, K, Yang, M, Schofield, C, Bennett, V, Yang, W, Marszalek, P   +7 more
openaire   +3 more sources

The toxins of vertically transmitted Spiroplasma

Frontiers in Microbiology, 2023
Vertically transmitted (VT) microbial symbionts play a vital role in the evolution of their insect hosts. A longstanding question in symbiont research is what genes help promote long-term stability of vertically transmitted lifestyles.
Logan D. Moore, Matthew J. Ballinger
doaj   +1 more source

Broad-Spectrum Antiviral Activity of an Ankyrin Repeat Protein on Viral Assembly against Chimeric NL4-3 Viruses Carrying Gag/PR Derived from Circulating Strains among Northern Thai Patients

Viruses, 2018
Certain proteins have demonstrated proficient human immunodeficiency virus (HIV-1) life cycle disturbance. Recently, the ankyrin repeat protein targeting the HIV-1 capsid, AnkGAG1D4, showed a negative effect on the viral assembly of the HIV-1NL4-3 ...
Supachai Sakkhachornphop, Sudarat Hadpech, Tanchanok Wisitponchai, Chansunee Panto, Doungnapa Kantamala, Utaiwan Utaipat, Jutarat Praparattanapan, Wilai Kotarathitithum, Sineenart Taejaroenkul, Umpa Yasamut, Koollawat Chupradit, Sutpirat Moonmuang, Vannajan Sanghiran Lee, Khuanchai Suparatpinyo, Chatchai Tayapiwatana   +14 more
doaj   +1 more source