Results 1 to 10 of about 28,994 (108)

Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium [PDF]

Frontiers in Molecular Neuroscience, 2023
IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an ...
Nicolas H. Piguel, Shaun S. Sanders, Francesca I. De Simone, Maria D. Martin-de-Saavedra, Maria D. Martin-de-Saavedra, Emmarose McCoig, Leonardo E. Dionisio, Katharine R. Smith, Gareth M. Thomas, Peter Penzes, Peter Penzes, Peter Penzes   +11 more
doaj   +2 more sources

TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance [PDF]

Cell Reports, 2020
Summary: Signaling by the cytokine transforming growth factor β (TGF-β) has been implicated in a multitude of biological functions; however, TGF-β signaling, particularly in the CNS, remains largely unexplored.
Sehyoun Yoon, Euan Parnell, Peter Penzes
doaj   +2 more sources

Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance [PDF]

Nature Communications, 2023
E-cadherin is an essential cell‒cell adhesion protein that mediates canonical cadherin-catenin complex formation in epithelial lateral membranes.
Chao Kong, Xiaozhan Qu, Mingming Liu, Weiya Xu, Da Chen, Yanshen Zhang, Shan Zhang, Feng Zhu, Zhenbang Liu, Jianchao Li, Chengdong Huang, Chao Wang   +11 more
doaj   +2 more sources

Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]

Biomolecules
The axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu, Yanyan Yu, Zhuqian Jiang, Yoshinori Otani, Masashi Fujitani   +4 more
doaj   +2 more sources

Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice [PDF]

eLife
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since
Christian Thome, Jan Maximilian Janssen, Seda Karabulut, Claudio Acuna, Elisa D'Este, Stella J Soyka, Konrad Baum, Michael Bock, Nadja Lehmann, Johannes Roos, Nikolas A Stevens, Masashi Hasegawa, Dan A Ganea, Chloé M Benoit, Jan Gründemann, Lia Y Min, Kalynn M Bird, Christian Schultz, Vann Bennett, Paul M Jenkins, Maren Engelhardt   +20 more
doaj   +2 more sources

Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc [PDF]

eLife, 2020
We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density.
Hua-Qian Yang, Marta Pérez-Hernández, Jose Sanchez-Alonso, Andriy Shevchuk, Julia Gorelik, Eli Rothenberg, Mario Delmar, William A Coetzee   +7 more
doaj   +2 more sources

Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia [PDF]

Frontiers in Cellular Neuroscience
The axon initial segment (AIS) is essential for initiating action potentials and maintaining neuronal polarity, yet the developmental roles of its core molecular components—Neurofascin 186 (NF186) and Ankyrin G (AnkG)—remain incompletely defined in ...
Qian Shi, Anna M. Taylor, Anna M. Taylor, Lacey B. Sell, Manzoor A. Bhat   +4 more
doaj   +2 more sources

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability [PDF]

Nature Communications
Recent studies have revealed many alternative exons differentially spliced across diverse neuron types in the mammalian brain, but their links to neuronal physiology remain unclear.
Shah Alam, Georgia Dermentzaki, David Cabrera-Garcia, Miao Li, Ruizhi Wang, Melissa Campbell, Ilaria Balbo, Brittany L. Phillips, Min Li, Jessica Estrada, Marianna Zazhytska, Yow-Tyng Yeh, Lia Min, Elizabeth Rafikian, Elizabeth Valenzuela, Brian Joseph, Tulsi Patel, Dmytro Ustianenko, Helene Lovett, Huijuan Feng, Xiaojian Wang, Susan Brenner-Morton, Chyuan-Sheng Lin, Clarissa L. Waites, Hynek Wichterle, Lizhen Chen, Mu Yang, Edmund Au, Marko Jovanovic, Stavros Lomvardas, Paul M. Jenkins, Rui Yang, Sheng-Han Kuo, Yueqing Peng, Guang Yang, Neil L. Harrison, Chaolin Zhang   +36 more
doaj   +2 more sources

Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart. [PDF]

PLoS ONE, 2013
Cardiac Na channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart. Recent studies show that Nav1.5 assembly and function are linked to ankyrin-G, gap, and mechanical junction
Wen Dun, John S Lowe, Patrick Wright, Thomas J Hund, Peter J Mohler, Penelope A Boyden   +5 more
doaj   +2 more sources

Correction: Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

eLife
Christian Thome, Jan Maximilian Janssen, Seda Karabulut, Claudio Acuna, Elisa D'Este, Stella J Soyka, Konrad Baum, Michael Bock, Nadja Lehmann, Johannes Roos, Nikolas A Stevens, Masashi Hasegawa, Dan A Ganea, Chloé M Benoit, Jan Gründemann, Lia Y Min, Kalynn M Bird, Christian Schultz, Vann Bennett, Paul M Jenkins, Maren Engelhardt   +20 more
doaj   +2 more sources