Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice [PDF]
eLife, 2023 The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since
Christian Thome +20 more
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Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium [PDF]
Frontiers in Molecular Neuroscience, 2023 IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an ...
Nicolas H. Piguel +11 more
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Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc [PDF]
eLife, 2020 We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density.
Hua-Qian Yang +7 more
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Roles and mechanisms of ankyrin-G in neuropsychiatric disorders. [PDF]
Exp Mol Med, 2022 AbstractAnkyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD).
Yoon S, Piguel NH, Penzes P.
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Giant ankyrin-G regulates cardiac function. [PDF]
J Biol Chem, 2021 Cardiovascular disease (CVD) remains the most common cause of adult morbidity and mortality in developed nations. As a result, predisposition for CVD is increasingly important to understand. Ankyrins are intracellular proteins required for the maintenance of membrane domains.
Cavus O +15 more
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TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance [PDF]
Cell Reports, 2020 Summary: Signaling by the cytokine transforming growth factor β (TGF-β) has been implicated in a multitude of biological functions; however, TGF-β signaling, particularly in the CNS, remains largely unexplored.
Sehyoun Yoon, Euan Parnell, Peter Penzes
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Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance [PDF]
Nature Communications, 2023 E-cadherin is an essential cell‒cell adhesion protein that mediates canonical cadherin-catenin complex formation in epithelial lateral membranes.
Chao Kong +11 more
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An unfolding role for ankyrin-G at the axon initial segment. [PDF]
Proc Natl Acad Sci U S A, 2019 The ability of neurons to integrate convergent inputs and generate action potentials, the physiological currency of activity, relies on the axon initial segment (AIS). This specialized segment of the proximal axon is the site of electrogenesis in neurons (1), reflecting its striking enrichment in voltage-gated sodium channels (NaV).
Salzer JL.
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Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]
BiomoleculesThe axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu +4 more
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Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. [PDF]
Mol Psychiatry, 2020 GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key role in the regulation of GABAergic synapses on the axon initial ...
Nelson AD +15 more
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