Dynamic spectrin/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis. [PDF]
Sci Adv, 2015 Locally dynamic micrometer-scale domains based on spectrin and ankyrin-G determine membrane identity by preventing endocytosis.
Jenkins PM, He M, Bennett V.
europepmc +3 more sources
Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Excitable axonal membrane microdomains are unique features of vertebrate nervous systems that are required for normal neuronal signaling and are involved in human neurological disorders. Ankyrin-G is a critical adaptor protein that acquired a giant exon early in vertebrate evolution, resulting in a new nervous system ...
Jenkins PM +6 more
europepmc +4 more sources
Reframing the axon initial segment: Giant ankyrin-G as a modulator of excitability and plasticity in neurodevelopment. [PDF]
Proc Natl Acad Sci U S ALopez AY, Jenkins PM.
europepmc +4 more sources
Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters
Channels, 2022 The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
doaj +1 more source
Exon organization and novel alternative splicing of Ank3 in mouse heart. [PDF]
PLoS ONE, 2015 Ankyrin-G is an adaptor protein that links membrane proteins to the underlying cytoskeletal network. Alternative splicing of the Ank3 gene gives rise to multiple ankyrin-G isoforms in numerous tissues.
Gokay Yamankurt +3 more
doaj +1 more source
Restriction of 480/270-kD Ankyrin G to Axon Proximal Segments Requires Multiple Ankyrin G-specific Domains [PDF]
The Journal of Cell Biology, 1998 AnkyrinG (−/−) neurons fail to concentrate voltage-sensitive sodium channels and neurofascin at their axon proximal segments, suggesting that ankyrinG is a key component of a structural pathway involved in assembly of specialized membrane domains at axon proximal segments and possibly nodes of Ranvier (Zhou, D., S. Lambert, D.L. Malen, S. Carpenter, L.
X, Zhang, V, Bennett
openaire +2 more sources
Identification of AnkG107, a Muscle-specific Ankyrin-G Isoform [PDF]
Journal of Biological Chemistry, 2002 We previously showed that alternatively spliced ankyrins-G, the Ank3 gene products, are expressed in skeletal muscle and localize to the postsynaptic folds and to the sarcoplasmic reticulum. Here we report the molecular cloning, tissue expression, and subcellular targeting of Ank(G107), a novel ankyrin-G from rat skeletal muscle.
Gagelin, Claire +8 more
openaire +3 more sources
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. [PDF]
PLoS Genetics, 2016 In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion ...
Timothy Jegla +9 more
doaj +1 more source
The ankyrin repeats and DHHC S-acyl transferase domain of AKR1 act independently to regulate switching from vegetative to mating states in yeast. [PDF]
PLoS ONE, 2011 Signal transduction from G-protein coupled receptors to MAPK cascades through heterotrimeric G-proteins has been described for many eukaryotic systems.
Piers A Hemsley, Claire S Grierson
doaj +1 more source
Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. [PDF]
PLoS ONE, 2016 The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied ...
Michael C Stankewich +4 more
doaj +1 more source