Results 11 to 20 of about 29,259 (193)

Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. [PDF]

J Biol Chem, 2016
Dynamic regulation of endothelial cell adhesion is central to vascular development and maintenance. Furthermore, altered endothelial adhesion is implicated in numerous diseases. Therefore, normal vascular patterning and maintenance require tight regulation of endothelial cell adhesion dynamics. However, the mechanisms that control junctional plasticity
Cadwell CM, Jenkins PM, Bennett V, Kowalczyk AP.   +3 more
europepmc   +4 more sources

Ankyrin G organizes membrane components to promote coupling of cell mechanics and glucose uptake. [PDF]

Nat Cell Biol, 2021
The response of cells to forces is critical for their function and occurs via rearrangement of the actin cytoskeleton1. Cytoskeletal remodelling is energetically costly2,3, yet how cells signal for nutrient uptake remains undefined. Here we present evidence that force transmission increases glucose uptake by stimulating glucose transporter 1 (GLUT1 ...
Salvi AM, Bays JL, Mackin SR, Mege RM, DeMali KA.   +4 more
europepmc   +4 more sources

Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. [PDF]

J Biol Chem, 2012
Ankyrin-G (AnkG) coordinates protein composition of diverse membrane domains, including epithelial lateral membranes and neuronal axon initial segments. However, how AnkG itself localizes to these membrane domains is not understood. We report that AnkG remains on the plasma membrane in Madin-Darby canine kidney (MDCK) cells grown in low calcium ...
He M, Jenkins P, Bennett V.
europepmc   +4 more sources

Correction: Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

eLife
Christian Thome, Jan Maximilian Janssen, Seda Karabulut, Claudio Acuna, Elisa D'Este, Stella J Soyka, Konrad Baum, Michael Bock, Nadja Lehmann, Johannes Roos, Nikolas A Stevens, Masashi Hasegawa, Dan A Ganea, Chloé M Benoit, Jan Gründemann, Lia Y Min, Kalynn M Bird, Christian Schultz, Vann Bennett, Paul M Jenkins, Maren Engelhardt   +20 more
doaj   +4 more sources

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure. [PDF]

JACC Basic Transl Sci, 2018
Ankyrin polypeptides are intracellular proteins responsible for targeting cardiac membrane proteins. Here, the authors demonstrate that ankyrin-G plays an unexpected role in normal compensatory physiological remodeling in response to myocardial stress and aging; the authors implicate disruption of ankyrin-G in human heart failure.
Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.   +13 more
europepmc   +3 more sources

Crystal structure of human Ankyrin G death domain. [PDF]

Proteins, 2014
ABSTRACTAnkyrins (Ank) are a ubiquitously expressed family of multifunctional membrane adapter proteins. Ankyrin G (AnkG) is critical for assembling and maintenance of the axon initial segment. Here we present the 2.1 Å crystal structure of human AnkG death domain (hAnkG‐DD). The core death domain is composed of six α‐helices and three 310‐helices.
Liu Y, Zhang Y, Wang JH.
europepmc   +4 more sources

Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia [PDF]

Frontiers in Cellular Neuroscience
The axon initial segment (AIS) is essential for initiating action potentials and maintaining neuronal polarity, yet the developmental roles of its core molecular components—Neurofascin 186 (NF186) and Ankyrin G (AnkG)—remain incompletely defined in ...
Qian Shi, Anna M. Taylor, Anna M. Taylor, Lacey B. Sell, Manzoor A. Bhat   +4 more
doaj   +2 more sources

Ankyrin-G Heterozygous Knockout Mice Display Increased Sensitivity to Social Defeat Stress. [PDF]

Complex Psychiatry, 2021
The ANK3 locus has been repeatedly found to confer an increased risk for bipolar disorder. ANK3 codes for Ankyrin-G (Ank-G), a scaffold protein concentrated at axon initial segments, nodes of Ranvier, and dendritic spines, where it organizes voltage-gated sodium and potassium channels and cytoskeletal proteins. Mice with homozygous conditional knockout
Cordner ZA, Khambadkone SG, Zhu S, Bai J, Forti RR, Goodman E, Tamashiro KLK, Ross CA.   +7 more
europepmc   +3 more sources

Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. [PDF]

Mol Psychiatry, 2017
ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in bipolar disorder by genome-wide association studies. ANK3 has multiple alternative first exons, and a bipolar disorder-associated ANK3 variant has been shown to reduce the expression of exon 1b.
Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, Cooper EC.   +9 more
europepmc   +4 more sources

Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

, 2023
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly post hoc approaches since no robust murine in vivo live reporters exist.
Thome C, Janssen JM, Karabulut S, Acuna C, D’Este E, Soyka SJ, Baum K, Bock M, Lehmann N, Roos J, Stevens NA, Hasegawa M, Ganea DA, Benoit CM, Gründemann J, Min L, Bird KM, Schultz C, Bennett V, Jenkins PM, Engelhardt M.   +20 more
europepmc   +4 more sources