Results 11 to 20 of about 9,109,837 (237)

NF-κB regulates neuronal ankyrin-G via a negative feedback loop. [PDF]

Sci Rep, 2017
AbstractThe axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation experiments in cortical neurons. Overexpression of the 270 kDa variant of ankyrin-G suppressed,
König HG, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, Prehn JH.   +6 more
europepmc   +8 more sources

Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. [PDF]

Mol Psychiatry, 2020
GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key role in the regulation of GABAergic synapses on the axon initial ...
Nelson AD, Caballero-Florán RN, Rodríguez Díaz JC, Hull JM, Yuan Y, Li J, Chen K, Walder KK, Lopez-Santiago LF, Bennett V, McInnis MG, Isom LL, Wang C, Zhang M, Jones KS, Jenkins PM.   +15 more
europepmc   +6 more sources

Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. [PDF]

Mol Psychiatry, 2015
Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple neuropsychiatric disorders, such as bipolar disorder, schizophrenia and autism spectrum disorder. Here,
Durak O, de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P, Tsai LH.   +6 more
europepmc   +8 more sources

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC). [PDF]

J Biol Chem, 2017
Research paper describing the interaction of the epithelial sodium channel (ENaC) and the scaffolding protein ankyrin G (AnkG) in renal collecting duct ...
Klemens CA, Edinger RS, Kightlinger L, Liu X, Butterworth MB.   +4 more
europepmc   +5 more sources

Dynamic spectrin/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis [PDF]

Science Advances, 2015
Locally dynamic micrometer-scale domains based on spectrin and ankyrin-G determine membrane identity by preventing endocytosis.
Paul M Jenkins, Vann Bennett
exaly   +4 more sources

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions

eLife, 2017
Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at ...
Keyu Chen, Jianchao Li, Chao Wang, Zhiyi Wei, Mingjie Zhang   +4 more
doaj   +2 more sources

Roles and mechanisms of ankyrin-G in neuropsychiatric disorders. [PDF]

Exp Mol Med, 2022
AbstractAnkyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD).
Yoon S, Piguel NH, Penzes P.
europepmc   +3 more sources

Giant ankyrin-G regulates cardiac function. [PDF]

J Biol Chem, 2021
Cardiovascular disease (CVD) remains the most common cause of adult morbidity and mortality in developed nations. As a result, predisposition for CVD is increasingly important to understand. Ankyrins are intracellular proteins required for the maintenance of membrane domains.
Cavus O, Williams J, Musa H, El Refaey M, Gratz D, Shaheen R, Schwieterman NA, Koenig S, Antwi-Boasiako S, Young LJ, Xu X, Han M, Wold LE, Hund TJ, Mohler PJ, Bradley EA.   +15 more
europepmc   +4 more sources

An unfolding role for ankyrin-G at the axon initial segment. [PDF]

Proc Natl Acad Sci U S A, 2019
The ability of neurons to integrate convergent inputs and generate action potentials, the physiological currency of activity, relies on the axon initial segment (AIS). This specialized segment of the proximal axon is the site of electrogenesis in neurons (1), reflecting its striking enrichment in voltage-gated sodium channels (NaV).
Salzer JL.
europepmc   +4 more sources

Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. [PDF]

J Biol Chem, 2016
Dynamic regulation of endothelial cell adhesion is central to vascular development and maintenance. Furthermore, altered endothelial adhesion is implicated in numerous diseases. Therefore, normal vascular patterning and maintenance require tight regulation of endothelial cell adhesion dynamics. However, the mechanisms that control junctional plasticity
Cadwell CM, Jenkins PM, Bennett V, Kowalczyk AP.   +3 more
europepmc   +4 more sources