Results 21 to 30 of about 29,259 (193)

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability [PDF]

Nature Communications
Recent studies have revealed many alternative exons differentially spliced across diverse neuron types in the mammalian brain, but their links to neuronal physiology remain unclear.
Shah Alam, Georgia Dermentzaki, David Cabrera-Garcia, Miao Li, Ruizhi Wang, Melissa Campbell, Ilaria Balbo, Brittany L. Phillips, Min Li, Jessica Estrada, Marianna Zazhytska, Yow-Tyng Yeh, Lia Min, Elizabeth Rafikian, Elizabeth Valenzuela, Brian Joseph, Tulsi Patel, Dmytro Ustianenko, Helene Lovett, Huijuan Feng, Xiaojian Wang, Susan Brenner-Morton, Chyuan-Sheng Lin, Clarissa L. Waites, Hynek Wichterle, Lizhen Chen, Mu Yang, Edmund Au, Marko Jovanovic, Stavros Lomvardas, Paul M. Jenkins, Rui Yang, Sheng-Han Kuo, Yueqing Peng, Guang Yang, Neil L. Harrison, Chaolin Zhang   +36 more
doaj   +2 more sources

Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment. [PDF]

Front Cell Neurosci, 2017
The axon initial segment (AIS) is a specialized neuronal compartment that plays a key role in neuronal development and excitability. It concentrates multiple ion channels and cell adhesion molecules. The anchoring of these AIS membrane components is known to be highly dependent of the scaffold protein ankyrin G (ankG) but whether ankG membrane partners
Leterrier C, Clerc N, Rueda-Boroni F, Montersino A, Dargent B, Castets F.   +5 more
europepmc   +5 more sources

NF-κB regulates neuronal ankyrin-G via a negative feedback loop. [PDF]

Sci Rep, 2017
AbstractThe axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation experiments in cortical neurons. Overexpression of the 270 kDa variant of ankyrin-G suppressed,
König HG, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, Prehn JH.   +6 more
europepmc   +5 more sources

Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. [PDF]

Dev Biol, 2019
Epithelial cell polarity, adhesion, proliferation, differentiation and survival are essential for morphogenesis of various organs and tissues including the ocular lens. The molecular mechanisms regulating the lens epithelial phenotype however, are not well understood.
Rasiah PK, Maddala R, Bennett V, Rao PV.
europepmc   +3 more sources

Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior. [PDF]

Proc Natl Acad Sci U S A
The developing brain undergoes neuroplasticity driven by learning, experience, and memory formation. The axon initial segment (AIS) is a specialized membrane domain within the proximal axon that initiates action potential. Studies have demonstrated that the AIS exhibits plasticity by altering its length and/or localization to ...
Li M, Zhao B, Lu Z, Zhe L, Han Y, Chen Y, Wang H, Wang Y, Wu C, Zhang M, Chen K, Yang R.   +11 more
europepmc   +4 more sources

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC). [PDF]

J Biol Chem, 2017
Research paper describing the interaction of the epithelial sodium channel (ENaC) and the scaffolding protein ankyrin G (AnkG) in renal collecting duct ...
Klemens CA, Edinger RS, Kightlinger L, Liu X, Butterworth MB.   +4 more
europepmc   +4 more sources

Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc [PDF]

Circulation Research, 2011
Rationale: The early description of the intercalated disc defined 3 structures, all of them involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions.
Kathleen Green, Mario Delmar, Lori L Isom   +2 more
exaly   +3 more sources

Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart. [PDF]

PLoS ONE, 2013
Cardiac Na channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart. Recent studies show that Nav1.5 assembly and function are linked to ankyrin-G, gap, and mechanical junction
Wen Dun, John S Lowe, Patrick Wright, Thomas J Hund, Peter J Mohler, Penelope A Boyden   +5 more
doaj   +2 more sources

Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. [PDF]

Mol Psychiatry, 2015
Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple neuropsychiatric disorders, such as bipolar disorder, schizophrenia and autism spectrum disorder. Here,
Durak O, de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P, Tsai LH.   +6 more
europepmc   +7 more sources

Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. [PDF]

Circ Res, 2014
Rationale: Na v 1.5 ( SCN5A ) is the primary cardiac voltage-gated Na v channel. Na v 1.5 is critical for cardiac excitability and conduction, and human SCN5A
Makara MA, Curran J, Little SC, Musa H, Polina I, Smith SA, Wright PJ, Unudurthi SD, Snyder J, Bennett V, Hund TJ, Mohler PJ.   +11 more
europepmc   +4 more sources