Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]
PLoS ONE, 2011 Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder +21 more
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Cytoskeletal regulation of ENaC: the role of ankyrin G (892.28)
The FASEB Journal, 2014 The epithelial sodium channel (ENaC) is a major determinant of sodium (Na+) and water balance in the kidney. The hormone aldosterone increases ENaC subunit translation and modifies expression of key regulators that alter ENaC function and membrane density.
Christine Klemens +3 more
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miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models
Cell Reports, 2014 MicroRNA alterations and axonopathy have been reported in patients with Alzheimer’s disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation is ...
Xiaqin Sun, Yu Wu, Mingxue Gu, Yan Zhang
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Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders
Cells, 2021 The 20–60 μm axon initial segment (AIS) is proximally located at the interface between the axon and cell body. AIS has characteristic molecular and structural properties regulated by the crucial protein, ankyrin-G.
Masashi Fujitani +2 more
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Neural Regeneration Research, 2021 The axon initial segment (AIS) region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels (Nav).
Piyush Bhardwaj +2 more
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Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold
Cell Reports, 2015 The axon initial segment (AIS), located within the first 30 μm of the axon, has two essential roles in generating action potentials and maintaining axonal identity.
Christophe Leterrier +5 more
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Molecular architecture of the Gαi-bound TRPC5 ion channel
Nature Communications, 2023 G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches through which extracellular stimuli are transformed into intracellular effects, and it has long been postulated that ion channels are direct effector molecules of the ...
Jongdae Won +10 more
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Enrichment of GABAA receptor α-subunits on the axonal initial segment shows regional differences
Frontiers in Cellular Neuroscience, 2016 Although it is generally recognized that certain α-subunits of γ-aminobutyric acid type A receptors (GABAARs) form enriched clusters on the axonal initial segment (AIS), the degree to which these clusters vary in different brain areas is not well known ...
Yudong eGao, Scott Allyn Heldt
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Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice [PDF]
Molecular Psychiatry, 2012 Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ...
Santuccione A C +14 more
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MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations
Journal of Pharmacological Sciences, 2021 Gentle touch such as stroking of the skin produces a pleasant feeling, which is detected by a rare subset of sensory neurons that express Mas-related G protein-coupled receptor B4 (MrgprB4) in mice.
Shota Tobori +8 more
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