Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Excitable axonal membrane microdomains are unique features of vertebrate nervous systems that are required for normal neuronal signaling and are involved in human neurological disorders. Ankyrin-G is a critical adaptor protein that acquired a giant exon early in vertebrate evolution, resulting in a new nervous system-specific ...
Jenkins PM +6 more
europepmc +4 more sources
Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice [PDF]
Molecular Psychiatry, 2012 Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ...
Santuccione A C +14 more
openaire +4 more sources
Ankyrin B and ankyrin G expression in cortex and medulla.
, 2016 (A&B) Immunofluorescent micrographs of ankyrin and α1-Na,K-ATPase in renal cortex and medulla. Both ankyrin B and G are found on both apical and basolateral membrane of tubule cells.
Michael C. Stankewich (842238) +4 more
core +1 more source
Enrichment of GABAA receptor α-subunits on the axonal initial segment shows regional differences
Frontiers in Cellular Neuroscience, 2016 Although it is generally recognized that certain α-subunits of γ-aminobutyric acid type A receptors (GABAARs) form enriched clusters on the axonal initial segment (AIS), the degree to which these clusters vary in different brain areas is not well known ...
Yudong eGao, Scott Allyn Heldt
doaj +1 more source
Molecular architecture of the Gαi-bound TRPC5 ion channel
Nature Communications, 2023 G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches through which extracellular stimuli are transformed into intracellular effects, and it has long been postulated that ion channels are direct effector molecules of the ...
Jongdae Won +10 more
doaj +1 more source
Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold
Cell Reports, 2015 The axon initial segment (AIS), located within the first 30 μm of the axon, has two essential roles in generating action potentials and maintaining axonal identity.
Christophe Leterrier +5 more
doaj +1 more source
MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations
Journal of Pharmacological Sciences, 2021 Gentle touch such as stroking of the skin produces a pleasant feeling, which is detected by a rare subset of sensory neurons that express Mas-related G protein-coupled receptor B4 (MrgprB4) in mice.
Shota Tobori +8 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
Cell Reports, 2023 Summary: Dysregulated neuronal excitability is a hallmark of amyotrophic lateral sclerosis (ALS). We sought to investigate how functional changes to the axon initial segment (AIS), the site of action potential generation, could impact neuronal ...
Peter Harley +9 more
doaj +1 more source
Immunoblot and immunofluorescent detection of ankyrin-G isoforms in heart.
, 2015 (A) Ankyrin-G immunoblot demonstrates expression of different isoforms in heart (arrows). Loss of ankyrin-G immunoreactive polypeptides in ankyrin-G null cerebellums demonstrates antibody specificity.
Henry C. Wu (747120) +3 more
core +1 more source