Results 81 to 90 of about 9,109,837 (237)

GFP-GABARAP colocalizes with ankyrin-G and MAP2.

, 2013
(A–H) The pyramidal neurons of the CA1 region of the hippocampus (A–D) and cerebellar Purkinje cells (E–H) of GFP-GABARAP transgenic mice were stained with antibodies to GFP (green), ankyrin-G (red) and MAP2 (blue).
Yasuo Uchiyama (209045), Masato Koike (209042), Isei Tanida (411585), Takashi Ueno (411589), Tomohisa Nanao (411586), Norihiro Tada (411587), Eiki Kominami (411590), Jun-ichi Iwata (411588)   +7 more
core   +1 more source

M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit [PDF]

, 2009
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle, Sophie Blanié, Blanié, Sophie, Christelle Camus-Bouclainville, Mortier, Jérémy, Stéphane Bertagnoli, Mortier, J, Maxence Delverdier, Bertagnoli, Stéphane, Jérémy Mortier, Delverdier, Maxence   +10 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

A period of structural plasticity at the axon initial segment in developing visual cortex

Frontiers in Neuroanatomy, 2014
Cortical networks are shaped by sensory experience and are most susceptible to modifications during critical periods characterized by enhanced plasticity at the structural and functional level.
Annika eGutzmann, Nursah eErguel, Nursah eErguel, Rebecca eGrossmann, Christian eSchultz, Christian eSchultz, Petra eWahle, Maren eEngelhardt, Maren eEngelhardt   +8 more
doaj   +1 more source

Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization

Advanced Science, 2023
HACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor, its structure and mode of ubiquitination are not understood.
Sunil Singh, Satoru Machida, Nikhil Kumar Tulsian, Yeu Khai Choong, Joel Ng, Srihari Shankar, Yaochen Liu, Krisha Vashdev Chandiramani, Jian Shi, J Sivaraman   +9 more
doaj   +1 more source

Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical Neurons

Life, 2023
Nucleoporins (NUPs) are proteins that comprise the nuclear pore complexes (NPCs). The NPC spans the nuclear envelope of a cell and provides a channel through which RNA and proteins move between the nucleus and the cytoplasm and vice versa.
Vladimir A. Martínez-Rojas, Francesca Pischedda, Isabel Romero-Maldonado, Bouchra Khalaf, Giovanni Piccoli, Paolo Macchi, Carlo Musio   +6 more
doaj   +1 more source

Decoding Ankyrin-G Targeting and Function [PDF]

, 2014
The spectrin-ankyrin network assembles diverse plasma membrane domains including axon initial segments and nodes of Ranvier, cardiomyocyte T-tubules and intercalated discs, epithelial lateral membranes, costameres and photoreceptor inner and outer ...
He, Meng
core  

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion [PDF]

Proceedings of the National Academy of Sciences, 2002
Nodes of Ranvier are excitable regions of axonal membranes highly enriched in voltage-gated sodium channels that propagate action potentials. The mechanism of protein clustering at nodes has been a source of controversy. In this study, developmental analysis of nodes of Ranvier in optic nerve axons reveals that early node intermediates are
Scott M, Jenkins, Vann, Bennett
openaire   +2 more sources

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source