Results 91 to 100 of about 9,109,837 (237)

Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group [PDF]

, 2007
BACKGROUND: Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes ...
Parkhill Julian, Sinkins, Steven P., Thomson Nicholas R, Sanders, Mandy J, Klasson Lisa, Walker, T, Sanders, MJ, Sebaihia, M, Parkhill, J, Sinkins Steven P, Klasson, L, Sanders, Mandy J., Klasson, Lisa, Thompson, Nicholas R., Sinkins, Steven P, Sanders Mandy J, Sebaihia, Mohammed, Sebalhia, Mohammed, Parkhill, Julian, Walker, Thomas, Thomson, Nicholas R, Walker Thomas, Thomson, Nicholas R., Sinkins, SP, Sebaihia Mohammed, Thomson, NR   +25 more
core   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

A Rare Variant of ANK3 Is Associated With Intracranial Aneurysm

Frontiers in Neurology, 2021
Intracranial aneurysm (IA) is a cerebrovascular disorder in which abnormal dilation of a blood vessel results from weakening of the blood vessel wall. The aneurysm may rupture, leading to subarachnoid hemorrhage with severe outcomes.
Junyu Liu, Xin Liao, Xin Liao, Jilin Zhou, Bingyang Li, Lu Xu, Songlin Liu, Yifeng Li, Dun Yuan, Chongyu Hu, Weixi Jiang, Junxia Yan, Junxia Yan   +12 more
doaj   +1 more source

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons

Journal of Cell Science, 2019
ABSTRACT Nup358 (also known as RanBP2) is a member of the large nucleoporin family that constitutes the nuclear pore complex. Depending on the cell type and the physiological state, Nup358 interacts with specific partner proteins and influences distinct mechanisms independent of its role in nucleocytoplasmic transport.
Bouchra Khalaf, Alessandro Roncador, Francesca Pischedda, Antonio Casini, Sabine Thomas, Giovanni Piccoli, Michael Kiebler, Paolo Macchi   +7 more
openaire   +3 more sources

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Ankyrin G Organizes Membrane Components to Promote Coupling of Cell Mechanics and Metabolism

The FASEB Journal, 2021
The response of cells to external forces is critical for their development, differentiation, and growth and occurs via rearrangement of the actin cytoskeleton. Cytoskeletal remodeling is energetically costly, yet how cells signal for nutrient uptake remains undefined. In this study, we present evidence that force signals for increased glucose uptake by
Kris DeMali, Alica Salvi, Jennifer Bays, Samantha Mackin   +3 more
openaire   +1 more source

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

BMC Neuroscience, 2017
Background Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function.
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald   +8 more
doaj   +1 more source

Ankyrin-G in skeletal muscle: Tissue-specific alternative splicing contributes to the complexity of the sarcolemmal cytoskeleton☆ [PDF]

Experimental Cell Research, 2005
Ankyrins are versatile adaptor proteins that join the spectrin-based cytoskeleton to transmembrane proteins, and have roles in organizing the microstructure of cell membranes. Molecular diversity of ankyrins in mammals arises from extensive alternative splicing of the products of three genes.
Hopitzan, Alexander, Baines, Anthony, Ludosky, Marie-Aline, Recouvreur, Michel, Kordeli, Ekaterini   +4 more
openaire   +3 more sources

Understanding the Role of Ankyrin-G in Synaptic Biology [PDF]

, 2019
Ankyrin-G is a fundamental scaffolding protein that organizes neuronal excitable membrane domains, including the axon initial segment (AIS) and nodes of Ranvier.
Nelson, Andrew
core