Results 111 to 120 of about 9,109,837 (237)

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease

MedComm
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid‐β (Aβ) and hyperphosphorylated tau.
Yu Li, Han Wang, Yiming Wang, Zhiya Chen, Yiqiong Liu, Wu Tian, Xinrui Kang, Abolghasem Pashang, Don Kulasiri, Xiaoli Yang, Hung Wing Li, Yan Zhang   +11 more
doaj   +1 more source

Alternative ankyrin-G SBD isoforms do not bind β-spectrin.

, 2015
(A) Diagram of Ank3 exon organizations for two rare ankyrin-G SBD variants (ΔE31 and ΔE28–31). Both variants lack a portion of the ZU5 motif. (B) β1-spectrin and β2-spectrin (repeats 13 to 17) binding to ankyrin-G SBDs (wildtype, Δ31, Δ28–31) was ...
Henry C. Wu (747120), Shane R. Cunha (747122), Gokay Yamankurt (747119), Michael McCarthy (747121)   +3 more
core   +1 more source

Reduced expression of ankyrin-G and E-cadherin in duodenal mucosal biopsy of subjects with celiac disease suggest its functional association with the disease pathology

, 2023
Background: Confirmatory diagnosis criteria of celiac disease (CD) include histological evaluation of duodenal tissue biopsy and titer of serum antibody against tissue trans-glutaminase (anti-tTG). Identification of tissue specific histological marker is
Vikram Narang, Sabyasachi Senapati, Nidhi Sharma, Ajit Sood, Vandana Midha   +4 more
core   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Mechanistic studies of ankyrin-B/ankyrin-G autoinhibition and regulation

, 2014
Ankyrins are a family of scaffold proteins, which serves to link great varieties of functional related but structurally diverse integral membrane proteins to the spectrin-based cytoskeletons.
Chen, Keyu
core  

Can trigeminal sensations impact saltiness perception? A mini‐review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan, Nicoletta Faraone, Matthew B McSweeney   +2 more
wiley   +1 more source

Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.

, 2004
We identify a human mutation (E1053K) in the ankyrin-binding motif of Na(v)1.5 that is associated with Brugada syndrome, a fatal cardiac arrhythmia caused by altered function of Na(v)1.5.
BENNETT V., LAMBERT S., RIVOLTA I., LEMAILLET G., MOHLER P. J., NAPOLITANO C., PRIORI, SILVIA GIULIANA   +6 more
core  

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Co-staining of Nav1.5 and ankyrin-G in non-infarcted and infarcted Purkinje cells.

, 2013
Panel A. Distribution of ankyrin-G and Nav1.5 protein in NZPFs (upper) and IZPFs (lower). Fixed Purkinje fibers were cryostat-sectioned (5 µm) longitudinally and labeled with anti-ankyrin-G and Nav1.5 antibodies.
Patrick Wright (470353), Thomas J. Hund (256356), Peter J. Mohler (35301), Penelope A. Boyden (256355), Wen Dun (256354), John S. Lowe (470352)   +5 more
core   +1 more source