Results 161 to 170 of about 881,355 (287)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity. [PDF]

PLoS Pathog
Hulswit RJG, Shamorkina TM, van der Lee J, Rosman F, Wetzels LS, van Kuppeveld FJM, Snijder J, Bosch BJ, Hurdiss DL.   +8 more
europepmc   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Evaluation of vaccine-induced antibody responses against SARS-CoV-2 in multiple myeloma patients from the northeastern region of Mexico. [PDF]

Hematol Transfus Cell Ther
Salazar-Riojas R, Alvarado-Navarro DM, Ruiz-de la Cruz ML, Castro-Fuentes LN, Vazquez-Hernandez KE, Gomez-Almaguer D, Rosas-Taraco AG.   +6 more
europepmc   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Neutralization of SARS-CoV-2 by IgM-14 via engagement of two distinct spike epitopes. [PDF]

PLoS Pathog
Wang Y, Hu Y, Ku Z, Yeung J, Zou J, Woodson M, Prokhorov NS, Knyazhanskaya ES, Zhao H, Sherman MB, An Z, Carroll SF, Shi PY, Leiman PG, Xie X.   +14 more
europepmc   +1 more source

Two‐Dimensional Reconfigurable Photodiode for In‐Sensor Color Filtering and Spectral Logic

Advanced Materials, EarlyView.
By harnessing the photodoping of different aggregates, the device exhibits wavelength‐dependent volatile‐to‐nonvolatile photoresponses that can be reconfigured via bias modulation. This enables in‐sensor color filtering and spectral‐encrypted information processing, eliminating reliance on external optical filters or post‐processing algorithms ...
Xiaokun Guo, Yaoqiang Zhou, Yufeng Zhang, Xinyi Zhao, Yue Pang, Lei Tong, Zhipei Sun, Jianbin Xu   +7 more
wiley   +1 more source

Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation. [PDF]

Sci Adv
Shoemaker SR, Luo M, Dam KA, Pak JE, Hoffmann MAG, Marqusee S.   +5 more
europepmc   +1 more source

Advanced Separators for Liquid and Quasi‐Solid Lithium Rechargeable Batteries: Design and Development

Advanced Materials, EarlyView.
This review traces the evolution of lithium‐ion battery separators from passive barriers to multifunctional components central to cell safety and performance. Polymer‐ceramic hybrids, nanofiber architectures, and bio‐derived membranes deliver ionic conductivities above 3 mS cm−1, thermal stability beyond 200 °C, and effective suppression of lithium ...
Karthik Vishweswariah, Ningaraju Gejjiganahalli Ningappa, Anil Kumar M. R., Jeremy I. G. Dawkins, Thiago M. G. Selva, Karim Zaghib   +5 more
wiley   +1 more source

Action Potential Dynamics During Spreading Depolarization. [PDF]

Cells
Vinokurova D, Mingazov B, Burkhanova-Zakirova G, Khazipov R, Nasretdinov A.   +4 more
europepmc   +1 more source