Results 171 to 180 of about 73,847 (203)

Stabilization of the Metastable Pre-Fusion Conformation of the SARS-CoV-2 Spike Glycoprotein through N-Linked Glycosylation of the S2 Subunit. [PDF]

Viruses
Zan F, Zhou Y, Chen T, Chen Y, Mu Z, Qian Z, Ou X.   +6 more
europepmc   +1 more source

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein [PDF]

Cell, 2020
SUMMARY The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main target of the humoral immune response ...
M Alejandra Tortorici, David Veesler, Alexandra Walls   +2 more
exaly   +6 more sources

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Structural Bioinformatics to Unveil Weaknesses of Coronavirus Spike Glycoprotein Stability

2021
Alternative strategies for developing antiviral drugs are needed, as vaccines could not be the final answer against the present SARS CoV-2 outbreak, due to the still existing ambiguities in the immunological response to the virus. Thus, SARS CoV-2 enzymes have been thoroughly investigated to develop their inhibitors as antiviral drugs. We have searched
Bongini P., Trezza A., Bianchini M., Spiga O., Niccolai N.   +4 more
openaire   +2 more sources

Biomimetic Molecularly Imprinted Nanogels for the Recognition of Spike Glycoproteins

ACS Applied Bio Materials
The rapid spread and mutation of SARS-CoV-2, the virus responsible for COVID-19, has set the foundation for extensive research into next-generation therapeutic strategies. A critical component of SARS-CoV-2 is the trimeric Spike (S) glycoprotein, which facilitates viral entry into host cells by interacting with the receptor-binding domain (RBD).
Iulia Elena Neblea, Tanţa-Verona Iordache, Andrei Sarbu, Anita-Laura Chiriac, Ana-Mihaela Gavrila, Bogdan Trica, Iuliana Elena Biru, Iuliana Caras, Mircea Teodorescu, François-Xavier Perrin, Anamaria Zaharia   +10 more
openaire   +2 more sources

Binding of Semliki Forest Virus and Its Spike Glycoproteins to Cells

European Journal of Biochemistry, 1979
We have studied the binding of the Semliki Forest virus and its isolated spike glycoproteins, in the form of water‐soluble octameric complexes, to various cells at 5°C. The number of viruses bound per cell increased strongly with increasing free concentrations of virus up to about 0.2 nM.
E, Fries, A, Helenius
openaire   +2 more sources

Modeling the structure of SARS-CoV spike glycoprotein

2004
The S1 and S2 subunits of the spike glycoprotein of SARS-CoV coronavirus have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with conventional homology and/or threading procedures.
NICCOLAI, NERI, SPIGA, OTTAVIA, BERNINI, ANDREA, Ciutti A., Chiellini S., Menciassi N.   +5 more
openaire   +1 more source

Cross-linking of the spike glycoproteins in Semliki Forest virus with dimethylsuberimidate

Virology, 1974
Abstract The bifunctional reagent dimethylsuberimidate was used to cross-link the proteins in: (1) intact Semliki Forest virus (SFV); (2) SFV containing a small amount of the detergent Triton X-100; (3) detergent released SFV membranes; (4) membranes solubilized with Triton X-100 into lipoprotein-detergent complexes; and (5) membranes solubilized ...
openaire   +2 more sources

Spike (S) Glycoprotein

2023
openaire   +1 more source

In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2

Journal of Biomolecular Structure and Dynamics, 2021
Lakshmana Rao Atmakuri, Vivek Chandramohan, Manikanta Murahari   +2 more
exaly