Results 221 to 230 of about 403,301 (348)

Computational approach for the design of potential spike protein binding natural compounds in SARS- CoV2 [PDF]

, 2020
Anamika Basu, Anasua Sarkar, Ujjwal Maulik   +2 more
openalex   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Development and Application of a Pseudovirus-Based Assay for Modelling SARS-CoV-2 Spike Protein Mediated Drug Screening. [PDF]

Int J Mol Sci
Khasanov SA, Esaulkova IL, Volobueva AS, Slita AV, Kriger DV, Tentler D, Yarovaya OI, Sokolova AS, Gorshkov AN, Dolgova AS, Lavrentieva IN, Dedkov VG, Salakhutdinov NF, Zarubaev VV.   +13 more
europepmc   +1 more source

Diminazene Aceturate Inhibits the Sars-Cov-2 Spike Protein-Induced Inflammation Involving Leukocyte Migration and DNA Extracellular Traps Formation

Gean Carlo Pereira‐Silva, Cassia K. C. A. Cornélio, Gabriella Pacheco, Natalia C. Rochael, Isaac Alef Barbosa Gomes, Aurilene Gomes Cajado, Katriane Carvalho da Silva, Barbara Simonson Gonçalves, Jairo R. Temerozo, Ruan Sousa Bastos, Jefferson Almeida Rocha, Leonardo Perez de Souza, Marcellus Henrique Loiola Ponte de Souza, Roberto César Pereira Lima‐Júnior, Jand Venes Rolim Medeiros, Marcelo de Carvalho Filgueiras, Dumith Chequer Bou‐Habib, Elvira M. Saraiva, Lucas Antônio Duarte Nicolau   +18 more
openalex   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Rapid Detection of SARS-CoV‑2 Spike Protein Using a Fully 3D-Printed Electrochemical Biosensor. [PDF]

ACS Omega
D'Amato DL, Caldas NM, de Faria LV, C Souza AB, Oliveira GP, O Costa D, de Sousa MOB, Dornellas RM, Ronconi CM.   +8 more
europepmc   +1 more source

Coronavirus-Induced Membrane Fusion Requires the Cysteine-Rich Domain in the Spike Protein

, 2000
Kevin W. Chang, YiWei Sheng, James L. Gombold   +2 more
openalex   +2 more sources

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Lactylation of the SARS-CoV-2 spike protein is required for viral infection. [PDF]

Signal Transduct Target Ther
Xin J, Wang C, Li Z, Gao W, Zhang W.
europepmc   +1 more source

The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour

, 2021
A. Sofia F. Oliveira, Deborah K. Shoemark, Amaurys Ávila Ibarra, Andrew D. Davidson, Imre Berger, Christiane Schaffitzel, Adrian J. Mulholland   +6 more
openalex   +1 more source