Results 201 to 210 of about 7,075,307 (355)
Spike Proteins May be Dangerous [PDF]
American Journal of Biomedical Science & Research, 2021 openaire +1 more source
SARS‐CoV‐2 Spike Protein‐Derived Cyclic Peptides as Modulators of Spike Interaction with GRP78
ChemBioChemAbstractThe human glucose‐regulated protein GRP78 is a human chaperone that translocactes to the cell surface when cells are under stress. Theoretical studies suggested it could be involved in SARS‐CoV‐2 virus entry to cells. In this work, we used in vitro surface plasmon resonance‐based assays to show that human GRP78 indeed binds to SARS‐CoV‐2 spike ...
Nicholas Johnson +5 more
openaire +2 more sources
Stretchable and Strain‐Tolerant Gold‐Coated Fibrous Biosensor for Superoxide Anion Monitoring
Advanced Materials Technologies, EarlyView.A breathable, stretchable gold nanomesh–TPU fiber platform is developed via controlled electroless deposition, enabling uniform through‐thickness conductivity while preserving porosity. Functionalized with superoxide dismutase, the system achieves selective, real‐time electrochemical detection of superoxide with high sensitivity, mechanical durability,
Jafar M. Batayneh, Ahyeon Koh
wiley +1 more source
At Home Detection of Ovarian Health Biomarker in Menstruation Blood
Advanced Materials Technologies, EarlyView.A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon +3 more
wiley +1 more source
Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently identified highly pathogenic swine coronavirus. In vitro, SADS-CoV can infect cell lines from many different species, including humans, highlighting its high zoonotic potential ...
Rafael Sanjuán +5 more
core +1 more source
Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity
Advanced Science, EarlyView.This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley +1 more source
Mutation hot spots in Spike protein of COVID-19 virus: Mutation in spike protein
Proceedings of the Indian National Science Academy, 2020 Upasana Ray, Arup Kumar Banerjee
openaire +1 more source
Spike gene variability in porcine epidemic diarrhea virus as a determinant for virulence
Journal of VirologyPorcine epidemic diarrhea virus (PEDV) is a pathogenic coronavirus that targets the swine intestinal tract, leading to acute diarrhea and high mortality in neonatal piglets.
Wentao Li +6 more
doaj +1 more source
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source