Results 181 to 190 of about 7,152,333 (341)

Causes and Consequences of Coronavirus Spike Protein Variability

Viruses
Coronaviruses are a large family of enveloped RNA viruses found in numerous animal species. They are well known for their ability to cross species barriers and have been transmitted from bats or intermediate hosts to humans on several occasions. Four of the seven human coronaviruses (hCoVs) are responsible for approximately 20% of common colds (hCoV ...
Fabian Zech, Christoph Jung, Timo Jacob, Frank Kirchhoff   +3 more
openaire   +5 more sources

Spike productivity in relation to yield as criterion for emmer wheat breeding [PDF]

, 2011
Landraces, which are unbred cereal species, and include in particular the tetraploid emmer wheat, have become an important focus for the activities of local or organic farmers, processors and consumers of organic products. This study is based on analyses
Capouchova, Ivana, Konvalina, Petr, Moudry, Jan, Moudry, Jan (Jr.), Stehno, Zdenek   +4 more
core  

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Spike Proteins May be Dangerous [PDF]

American Journal of Biomedical Science & Research, 2021
openaire   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Identification of new pharmacophore against SARS-CoV-2 spike protein by multi-fold computational and biochemical techniques

Scientific Reports
COVID-19 appeared as a highly contagious disease after its outbreak in December 2019 by the virus, named SARS-CoV-2. The threat, which originated in Wuhan, China, swiftly became an international emergency.
Atta Ullah, Saeed Ullah, Sobia Ahsan Halim, Muhammad Waqas, Basharat Ali, Farid S. Ataya, Nasser M. El-Sabbagh, Gaber El-Saber Batiha, Satya Kumar Avula, Rene Csuk, Ajmal Khan, Ahmed Al-Harrasi   +11 more
doaj   +1 more source

Anti‐Slip Material‐Based Strategies and Approaches

Advanced Materials Technologies, EarlyView.
This review highlights the principle mechanisms of slipping at the microscale, linking contact mechanics with a friction behavior model for surface interfaces. Main strategies to develop anti‐slip properties to the surfaces are discussed alongside standardized testing approaches.
Sogand Abbaspoor‐Zanjani, Carlo Antonini, Teresa Gatti, Mengjiao Wang   +3 more
wiley   +1 more source

The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin

Scientific Reports
We study the prevalence of SARS-CoV-2 antibodies in a diverse population in Milwaukee County, Wisconsin from May 2021 to June 2022. We find that 99.4% (523/526) of the participants had positive results for antibodies to the SARS CoV2 spike protein over ...
Lorenzo Franchi, Vladimir Atanasov, Mark Stake, Garrett Bates, Kristen Osinski, John R Meurer, Bernard Black   +6 more
doaj   +1 more source

Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct

Journal of Structural Biology: X
The SARS-CoV-2 spike protein is synthesized in the endoplasmic reticulum of host cells, from where it undergoes export to the Golgi and the plasma membrane or retrieval from the Golgi to the endoplasmic reticulum.
Suruchi Singh, Yi Liu, Meghan Burke, Vamseedhar Rayaprolu, Stephen E. Stein, S. Saif Hasan   +5 more
doaj   +1 more source