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Spike Protein Fragments Promote Alzheimer’s Amyloidogenesis

ACS Applied Materials & Interfaces, 2023
Alzheimer's disease (AD) is a major cause of dementia inducing memory loss, cognitive decline, and mortality among the aging population. While the amyloid aggregation of peptide Aβ has long been implicated in neurodegeneration in AD, primarily through the production of toxic polymorphic aggregates and reactive oxygen species, viral infection has a less
Sujian Cao   +8 more
openaire   +4 more sources

Thermal Spikes in Protein

Journal of Applied Physics, 1962
A formula is shown relating the temperature of an infinite medium through which a fission fragment passes with the distance from the axis defined by the fission-fragment track. This formula has cylindrical symmetry, and represents a temperature distribution that has a maximum at the track and falls off exponentially with the radius.
A. Norman, P. Spiegler
openaire   +1 more source

Cytoplasmic tail of coronavirus spike protein has intracellular targeting signals

open access: yesJournal of Biosciences, 2017
Intracellular trafficking and localization studies of spike protein from SARS and OC43 showed that SARS spike protein is localized in the ER or ERGIC compartment and OC43 spike protein is predominantly localized in the lysosome. Differential localization
Manmeet Singh, Jayasri Das Sarma
exaly   +2 more sources

Functional Domains in the Spike Protein of Transmissible Gastroenteritis Virus

1995
The coronavirus spike protein S is assumed to mediate essential biological functions, including recognition of target cells. Earlier studies from our and other groups identified two regions of the TGEV S (220K) protein possibly implicated in such functions. The first of these corresponds to the 224 amino acid N-terminal region which is deleted in PRCV,
Laude, Hubert   +5 more
openaire   +3 more sources

Construction of a Ball‐and‐Spike Protein Supramolecule

Angewandte Chemie International Edition, 2006
Kenji Sugimoto   +4 more
openaire   +2 more sources

Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein

Structure, 2022
Zhen Wah Tan   +2 more
exaly  

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