Results 61 to 70 of about 215,411 (303)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

The chronotron: a neuron that learns to fire temporally-precise spike patterns [PDF]

, 2010
In many cases, neurons process information carried by the precise timing of spikes. Here we show how neurons can learn to generate specific temporally-precise output spikes in response to input spike patterns, thus processing and memorizing information ...
Răzvan V. Florian
core  

An adaptive silicon synapse [PDF]

, 2003
Chicca E, Indiveri G, Douglas R. An adaptive silicon synapse. Presented at the Proceedings of the 2003 International Symposium on Circuits and Systems (ISCAS).We present an analog circuit for implementing models of synapses with short-term adaptation ...
Douglas, R., Indiveri, G., Chicca, Elisabetta ; https://orcid.org/   +2 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Exploiting device mismatch in neuromorphic VLSI systems to implement axonal delays [PDF]

, 2012
Axonal delays are used in neural computation to implement faithful models of biological neural systems, and in spiking neural networks models to solve computationally demanding tasks. While there is an increasing number of software simulations of spiking
Sadique Sheik, Sheik, S., Sheik, Sadique, Indiveri, G., Giacomo Indiveri, Elisabetta Chicca, Chicca, Elisabetta, Indiveri, Giacomo, Chicca, Elisabetta ; https://orcid.org/   +8 more
core   +1 more source

Neuron-like spiking dynamics in the asymmetrically-driven dissipative photonic Bose-Hubbard dimer

, 2022
We demonstrate neuron-like spiking dynamics in the asymmetrically driven dissipative photonic Bose-Hubbard dimmer model which describes two coupled nonlinear passive Kerr cavities. Spiking dynamics appear due to the excitable nature of the system.
Francois Leo (14366088), Pedro Parra-Rivas (12517987), Jesús Yelo-Sarrión (14386092), Simon-Pierre Gorza (14366085)   +3 more
core   +1 more source

A Transient Photoelectric Spiking Neuron Based on a Highly Robust MgO Composite Threshold Switching Memristor for Selective UV Perception

Advanced Electronic Materials
The biological photoreceptors in the retina convert light information into spikes, inspiring the emergence of artificial photoelectric spiking neurons. However, due to the lack of biocompatible and biodegradable characteristics, artificial photoelectric ...
Yaxiong Cao, Rui Wang, Saisai Wang, Tonglong Zeng, Wanlin Zhang, Jing Sun, Xiaohua Ma, Hong Wang, Yue Hao   +8 more
doaj   +1 more source

Gradient Descent Learning Algorithm for Spiking Neuron with Delay Adjustment [PDF]

Jisuanji gongcheng, 2019
The spiking neuron supervised learning algorithm adjusts the synaptic weight of the neuron by gradient descent method,but the accuracy gets low and the learning period gets long as the length of the target learning sequence increases.Therefore,a gradient
YANG Jing, XU Yan, ZHAO Xin
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Characterizing the firing properties of an adaptive analog VLSI neuron [PDF]

, 2004
Ben Dayan Rubin D, Chicca E, Indiveri G. Characterizing the firing properties of an adaptive analog VLSI neuron. Biologically Inspired Approaches to Advanced Information Technology.
Ben Dayan Rubin, D., Indiveri, G., Giacomo Indiveri, Daniel Ben Dayan Rubin, Elisabetta Chicca, Chicca, Elisabetta ; https://orcid.org/   +5 more
core   +1 more source