Results 51 to 60 of about 75,067 (283)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Brain-inspired nanophotonic spike computing: challenges and prospects

Neuromorphic Computing and Engineering, 2023
Nanophotonic spiking neural networks (SNNs) based on neuron-like excitable subwavelength (submicrometre) devices are of key importance for realizing brain-inspired, power-efficient artificial intelligence (AI) systems with high degree of parallelism and ...
Bruno Romeira, Ricardo Adão, Jana B Nieder, Qusay Al-Taai, Weikang Zhang, Robert H Hadfield, Edward Wasige, Matěj Hejda, Antonio Hurtado, Ekaterina Malysheva, Victor Dolores Calzadilla, João Lourenço, D Castro Alves, José M L Figueiredo, Ignacio Ortega-Piwonka, Julien Javaloyes, Stuart Edwards, J Iwan Davies, Folkert Horst, Bert J Offrein   +19 more
doaj   +1 more source

Prospective Coding by Spiking Neurons

PLOS Computational Biology, 2016
Animals learn to make predictions, such as associating the sound of a bell with upcoming feeding or predicting a movement that a motor command is eliciting. How predictions are realized on the neuronal level and what plasticity rule underlies their learning is not well understood.
Johanni Brea, Alexisz Tamás Gaál, Robert Urbanczik, Walter Senn   +3 more
openaire   +4 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Performing Arithmetic Operations with Locally Homogeneous Spiking Neural P Systems

Applied Sciences, 2023
The parallelism of rule execution in membrane computing provides support for improving computational efficiency. Membrane computing models have been applied in many fields.
Xu Zhang, Zongrong Hu, Jingyi Li, Ran Liu   +3 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

In Materia Neuron Spiking Plasticity for Sequential Event Processing Based on Dual‐Mode Memristor

Advanced Intelligent Systems, 2022
Artificial neurons are the fundamental elements in neuromorphic computing systems. Studies have revealed neuronal spike‐rate adaptation owing to intrinsic plasticity that neurons will adapt to the spiking patterns and store the events in the background ...
Linbo Shan, Zongwei Wang, Lin Bao, Shengyu Bao, Yabo Qin, Yaotian Ling, Guandong Bai, John Robertson, Yimao Cai, Ru Huang   +9 more
doaj   +1 more source

On The Delays In Spiking Neural P Systems

, 2012
In this work we extend and improve the results done in a previous work on simulating Spiking Neural P systems (SNP systems in short) with delays using SNP systems without delays.
Adorna, Henry N., Buño, Kelvin C., Cabarle, Francis George C.   +2 more
core   +1 more source

Fluctuation-Dissipation Relations for Spiking Neurons

Physical Review Letters, 2022
Spontaneous fluctuations and stimulus response are essential features of neural functioning but how they are connected is poorly understood. I derive fluctuation-dissipation relations (FDR) between the spontaneous spike and voltage correlations and the firing rate susceptibility for i) the leaky integrate-and-fire (IF) model with white noise; ii) an IF
openaire   +3 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source