Results 71 to 80 of about 222,373 (293)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Effect of poly(ethylene glycol)-based cross-linker length on the physicochemical and rheological properties of hyaluronic acid hydrogels potentially applicable in the biomedical field

open access: yesCarbohydrate Polymer Technologies and Applications
The development of safe and effective hyaluronic acid-based materials is one of the main research focuses for biomedical applications. However, so far, an investigation of the influence of the cross-linker chain length on the physicochemical, mechanical,
Fabiana Cordella   +11 more
doaj   +1 more source

Sustainability Assessment of the Green Compost Production Chain from Agricultural Waste: A Case Study in Southern Italy

open access: yesAgronomy, 2020
Horticultural farms are faced with the problem of disposing of huge amounts of agricultural by-products whose management requires sustainable solutions. Composting means to recycle organic waste to make compost—a high agronomic value product— ...
Maria Pergola   +6 more
doaj   +1 more source

Pixel Detectors for Tracking and their Spin-off in Imaging Applications

open access: yes, 2004
To detect tracks of charged particles close to the interaction point in high energy physics experiments of the next generation colliders, hybrid pixel detectors, in which sensor and read-out IC are separate entities, constitute the present state of the ...
Wermes, N.
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Flat Array Antennas for Ku-Band Mobile Satellite Terminals

open access: yesInternational Journal of Antennas and Propagation, 2009
This work presents the advances in the development of two innovative flat array antennas for Ku-band mobile satellite terminals. The first antenna is specifically conceived for double-deck trains to allow a bi-directional high data rate satellite link ...
Roberto Vincenti Gatti   +3 more
doaj   +1 more source

Why do scientists create academic spin-offs? The influence of the context [PDF]

open access: yes, 2014
The aim of this work is to examine the nature of academic spin-offs in a specific context: the Emilia-Romagna region (Italy). More specifically we investigate the individual reasons as to explain why scientists create academic spin-offs and how the ...
Rizzo, Ugo
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Repeating Routines? How transfer and inheritance to corporate spin-offs varies among gestation contexts [PDF]

open access: yes
In economic geography literature the attention for spin‐off entrepreneurship has been steadily growing. Its main driver is that spin-off firms are said to have intrinsic advantages over other start-ups because of their embedded link to a parent company ...
Florian Langstraat   +3 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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