Results 71 to 80 of about 2,427,104 (377)
Black hole state counting in loop quantum gravity
, 2011 The two ways of counting microscopic states of black holes in the U(1) formulation of loop quantum gravity, one counting all allowed spin network labels j,m and the other only m labels, are discussed in some detail. The constraints on m are clarified and
Ghosh, A., Mitra, P.
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Coherent states for FLRW space-times in loop quantum gravity
, 2011 We construct a class of coherent spin-network states that capture proprieties of curved space-times of the Friedmann-Lama\^itre-Robertson-Walker type on which they are peaked.
Abhay Ashtekar +7 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 Three 2´-deoxynucleosides containing semi-flexible spin labels, namely TA, UA and UC, were prepared and incorporated into deoxyoligonucleotides using the phosphoramidite method.
Dnyaneshwar B. Gophane +1 more
doaj +1 more source
Journal of Magnetic Resonance Open, 2022 Spectroscopic investigation of membrane proteins in their native environment is a challenging task. Earlier we demonstrated the feasibility to measure precise distances within outer membrane proteins in E.
Sophie Ketter +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Probing the Y2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements
Molecules, 2020 The function of G protein-coupled receptors is intrinsically linked to their conformational dynamics. In conjugation with site-directed spin labeling, electron paramagnetic resonance (EPR) spectroscopy provides powerful tools to study the highly dynamic ...
Jeannette M. Laugwitz +6 more
doaj +1 more source
Effective constraints of loop quantum gravity [PDF]
, 2006 Within a perturbative cosmological regime of loop quantum gravity corrections to effective constraints are computed. This takes into account all inhomogeneous degrees of freedom relevant for scalar metric modes around flat space and results in explicit ...
A. Ashtekar +10 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source