Results 61 to 70 of about 1,952,657 (357)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An unusual presentation of spontaneous spinal epidural hematoma

Journal of the American College of Emergency Physicians Open, 2023
We report a rare case of spontaneous spinal epidural hematoma. Various presentations may occur, most commonly including neck pain, interscapular pain, radicular pain, and paralysis.
Brian L. Risavi, Erin M. Reese, Mary Knott   +2 more
doaj   +1 more source

Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts. [PDF]

, 2019
Neural progenitor cell grafts form new relays across sites of spinal cord injury (SCI). Using a panel of neuronal markers, we demonstrate that spinal neural progenitor grafts to sites of rodent SCI adopt diverse spinal motor and sensory interneuronal ...
Kadoya, Ken, Kumamaru, Hiromi, Lu, Paul, Rosenzweig, Ephron S, Tuszynski, Mark H   +4 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Patterns of lipofuscin accumulation in ganglionic nerve cells of superior cervical ganglion in humans [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals.
Živković Vladimir, Stefanović Natalija, Đurović-Filipović Tatjana, Pavlović Snežana, Stojanović Vesna, Bakić Mirjana, Kundalić Braca, Pavlović Miljana   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Electrical safety in spinal cord stimulation: current density analysis by computer modeling [PDF]

, 1995
The possibility of tissue damage in spinal cord stimulation was investigated in a computer modeling study. A decrease of the electrode area in monopolar stimulation resulted in an increase of the current density at the electrode surface.
Holsheimer, J., Wesselink, W.A.
core   +3 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Norepinephrine Versus Phenylephrine for the Prevention of Post Spinal Hypotension in Caesarean Section.

Journal of Karnali Academy of Health Sciences, 2022
Background: Hypotension following spinal anesthesia in the cesarean section is common despite adequate fluid loading. The recommended medication to treat spinal hypotension during cesarean section is phenylephrine. Norepinephrine bolus has recently been
Nabin Thapa, Pradip Raj Vaidya, Sangeeta Shrestha, Sabina Thapa   +3 more
doaj  

Extradural spinal meningioma: Revisiting a rare entity

Journal of Craniovertebral Junction and Spine, 2016
Spinal meningiomas are mostly intradural in location although at times these are associated with some extradural extensions. Purely extradural spinal meningiomas (EDSMs) are however, extremely rare and when present, may cause diagnostic dilemma ...
Guruprasad Bettaswamy, Paurush Ambesh, Kuntal Kanti Das, Rabi Sahu, Arun Srivastava, Anant Mehrotra, Awadhesh Jaiswal, Sushila Jaiswal, Sanjay Behari   +8 more
doaj   +1 more source