Results 61 to 70 of about 1,508,695 (362)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

The PEG-coated collagen patch Hemopatch® for hemostasis and dural sealing in neurosurgery

Frontiers in Surgery
BackgroundPostoperative cerebrospinal fluid (CSF) leakage and bleeding are major postoperative complications that increase healthcare system costs.
Jakob Rossmann, Apio C. M. Antunes, Guy G. Broc, Danny T. M. Chan, Se-Yi Chen, Nicolas Dea, Jacob Fairhall, Pablo de Andrés Guijarro, Nicola Montano, Karl-Michael Schebesch, Jake Timothy, Vamsi Krishna Yerramneni   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Patterns of lipofuscin accumulation in ganglionic nerve cells of superior cervical ganglion in humans [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals.
Živković Vladimir, Stefanović Natalija, Đurović-Filipović Tatjana, Pavlović Snežana, Stojanović Vesna, Bakić Mirjana, Kundalić Braca, Pavlović Miljana   +7 more
doaj   +1 more source

Perceptions of gain following spinal cord injury : A qualitative analysis

, 2013
Background: Significant research has focused on psychological difficulties following spinal cord injury (SCI), and there is a small prevalence of individuals who experience distress after injury.
Kennedy, P.,, Elfström, Magnus,, Cox, A.,, Lude, P.,   +3 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Norepinephrine Versus Phenylephrine for the Prevention of Post Spinal Hypotension in Caesarean Section.

Journal of Karnali Academy of Health Sciences, 2022
Background: Hypotension following spinal anesthesia in the cesarean section is common despite adequate fluid loading. The recommended medication to treat spinal hypotension during cesarean section is phenylephrine. Norepinephrine bolus has recently been
Nabin Thapa, Pradip Raj Vaidya, Sangeeta Shrestha, Sabina Thapa   +3 more
doaj  

Extradural spinal meningioma: Revisiting a rare entity

Journal of Craniovertebral Junction and Spine, 2016
Spinal meningiomas are mostly intradural in location although at times these are associated with some extradural extensions. Purely extradural spinal meningiomas (EDSMs) are however, extremely rare and when present, may cause diagnostic dilemma ...
Guruprasad Bettaswamy, Paurush Ambesh, Kuntal Kanti Das, Rabi Sahu, Arun Srivastava, Anant Mehrotra, Awadhesh Jaiswal, Sushila Jaiswal, Sanjay Behari   +8 more
doaj   +1 more source