Results 61 to 70 of about 36,129 (260)

A Lightweight, 3D‐Printable, Low‐Cost, “One‐Click” Dorsal Skin Window for High‐Quality Long‐Term Multimodal Subcutaneous Tumor Imaging

Advanced Healthcare Materials, EarlyView.
An innovative, lightweight 3D‐printed skinfold chamber system is presented for long‐term intravital imaging. This affordable, biocompatible platform simplifies surgical implantation and allows high‐resolution, multimodal visualization of the tumor microenvironment for up to four weeks.
Iván Cortés Domínguez, Xabier Morales Urteaga, Maider Esparza, Lucía Grande, Ainhoa Urbiola, Cristina Ederra, Tomas Muñoz Santoro, Beatrice Pinci, Alvaro Teijeira, Carlos Ortiz de Solórzano   +9 more
wiley   +1 more source

Mechanically Compliant, Precision‐Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Advanced Healthcare Materials, EarlyView.
This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg, Le Zhen, Rebecca Darrow, Savannah Lawton, Lars Crawford, Robert Robinson, Steve Perlmutter, James D. Bryers, Buddy D. Ratner   +8 more
wiley   +1 more source

Maskless Fabrication of PLA‐Based Neural Arrays for CNS Recording and Stimulation

Advanced Materials Interfaces, EarlyView.
Biodegradable neural interfaces enable bidirectional communication with the CNS. Through electrochemical characterization, ageing tests with impedance monitoring, and in vivo validation, we assess the performance of PLA‐based epicortical and spinal implants.
Anna De Salvo, Federica Velluto, Ilenia Sergi, Michele Di Lauro, Verónica Barranco‐Maresca, Elena Alonso‐Calviño, Yasmina Hernández‐Martín, Juan Aguilar, Juliana M. Rosa, María C. Serrano, Carolina Giulia Ferroni, Federico Rondelli, Elisa López‐Dolado, Luciano Fadiga, Fabio Biscarini   +14 more
wiley   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: a multi- center prospective observational study

BMC Anesthesiology
Background Failed spinal anaesthesia causes prolonging of operation time, insufficient analgesia for surgery and needs repeating spinal anaesthesia which in turn causes local anaesthesia toxicity, high spinal and total spinal, and conversion to general ...
Atalay Eshetie Demilie, Zewditu Abdissa Denu, Yosef Belay Bizuneh, Endale Gebreegziabher Gebremedhn   +3 more
doaj   +1 more source

Efficacy of Preoperative Pericapsular Nerve Group Block in Patients with Hip Fracture and its Effect on the Success of Spinal Anaesthesia: A Retrospective Study

Turkish Journal of Anaesthesiology and Reanimation
Objective: We intended to research the efficacy of pericapsular nerve group (PENG) block performed with preoperative ultrasonography (USG) in patients who underwent hip fracture repair under spinal anaesthesia and whether it affects the success of spinal
Burcu Kaplan, Eyyüp Sabri Özden, Mustafa Soner Özcan, Filiz Alkaya Solmaz, Pakize Kırdemir   +4 more
doaj   +1 more source

Laparoscopic cholecystectomy under spinal anaesthesia: A prospective, randomised study

Journal of Minimal Access Surgery, 2013
Context: Spinal anaesthesia has been reported as an alternative to general anaesthesia for performing laparoscopic cholecystectomy (LC). Aims: Study aimed to evaluate efficacy, safety and cost benefit of conducting laparoscopic cholecystectomy under ...
Sangeeta Tiwari, Ashutosh Chauhan, Pallab Chaterjee, Mohammed T Alam   +3 more
doaj   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source