Results 111 to 120 of about 567,269 (308)

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Acute Paraplegia after General Anesthesia [PDF]

Acta Medica Iranica, 2011
Acute paraplegia is a rare but catastrophic complication of surgeries performed on aorta and corrective operations of vertebral column. Trauma to spinal cord after spinal anesthesia and ischemia of spinal cord also may lead to acute paraplegia.
Siamak Afshinmajd, Alireza Khalaj, Younes Roohani, Mohammadebrahim Yarmohammadi, Shadi Salehpour, Alireza Saeedi, Gholam Hossein Ghaedi, Mehran Heydari Seradj   +7 more
doaj   +1 more source

Effect of Different Methods of Skin Infiltration of Local Anesthetics on Pain during Spinal Anesthesia Induction

مجله دانشکده پزشکی اصفهان, 2013
Background: Spinal anesthesia needs needle insertion through the skin into the subarachnoid space. In most patients, this insertion causes pain which leads to discomfort, stress, unintended moving and finally, failure in spinal block.
Sayed Jalal Hashemi, Gholam-Reza Khalili, Samanehsadat Moosavi   +2 more
doaj  

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Hypotension and bradycardia before spinal anesthesia

, 2017
I report a case of hypotension and bradycardia before spinal anesthesia in a pregnant woman with mild to moderate hypertension treated with nifedipine and methyldopa, scheduled for an elective cesarean delivery.
Shiraishi-Zapata, Carlos Javier, Zapata,Carlos Javier Shiraishi, Carlos Javier Shiraishi Zapata   +2 more
core   +2 more sources

Vasopressors for hypotension in spinal anesthesia for cesarean section

We read with great interest the article "Epinephrine vs. phenylephrine infusion for prophylaxis against maternal hypotension after spinal anesthesia for cesarean delivery: a randomized controlled trial" by Yasmin S. Hassabelnaby and colleagues [1]
Bilotta, Federico, Cipriani, Gianni, Malja, Endrit, Biava, Anna Maria   +3 more
core   +1 more source

YouTube as an information source of spinal anesthesia, epidural anesthesia and combined spinal and epidural anesthesia

, 2017
IntroductionSocial media as YouTube have become a part of daily life and many studies evaluated health-related YouTube videos. Our aim was to evaluate videos available on YouTube for the conformity to textbook information and their sufficiency as a ...
Ozgur Senturk, Zeliha Ozer, Serifsoy,Talat Ercan, Talat Ercan Serifsoy, Senturk,Ozgur, Onur Selvi, Tulgar,Serkan, Ozer,Zeliha, Selvi,Onur, Serkan Tulgar   +9 more
core   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Spinal cord ischemia following thoracotomy without epidural anesthesia

, 2006
Paraplegia is an uncommon yet devastating complication following thoracotomy, usually caused by compression or ischemia of the spinal cord. Ischemia without compression may be a result of global ischemia, vascular injury and other causes.
Saute, Milton, Raz, Aeyal, Avramovich, Aharon, Saraf-Lavi, Efrat, Eidelman, Leonid A, Efrat Saraf-Lavi, Leonid A. Eidelman, Aeyal Raz, Aharon Avramovich, Milton Saute   +9 more
core   +1 more source