Results 121 to 130 of about 174,410 (337)
Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye+13 more
wiley +1 more source
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski+3 more
wiley +1 more source
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong+15 more
wiley +1 more source
Comparison of Local and Spinal Anesthesia for Inguinal Hernia Repair
Inguinal hernial repair is one of the most common surgical procedures in a general surgical practice. The usual anesthetic methods for elective inguinal herniorrhaphy are spinal or local anesthesia.
Bunlue Chowdok, Araya Khaimook
doaj
AN EVALUATION OF HYPOBARIC PONTOCAINE FOR SPINAL ANESTHESIA WITH A REPORT OF 200 CASES [PDF]
J. Eugene Ruben, EDWIN M. KISTLER
openalex +1 more source
BMSC‐NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration
A novel strategy for integrated osteochondral tissue regeneration using BMSC‐NFMCs, this study has demonstrated the precise regulation of vascularization and effective interface integration using optimized nanofibrous materials and innovative construction methods.
Qian Zhou+8 more
wiley +1 more source
Effect of Hypotension due to Spinal Anesthesia on Coronary Blood Flow and Myocardial Metabolism in Man [PDF]
Donald B. Hackel+2 more
openalex +1 more source
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia+8 more
wiley +1 more source
THE SPREAD OP DRUGS USED FOR SPINAL ANESTHESIA [PDF]
Tetsuo Kitahara+2 more
openalex +1 more source
The study of intravenous pethidine efficacy in prevention of shivering during cesarean section under spinal anesthesia [PDF]
Background: shivering is an important and unpleasant complication of anesthesia which is reported in 5-65 and 55 percent of general and neuraxial anesthesia respectively.
Izanloo, Elaham
core