Results 51 to 60 of about 174,410 (337)
DexaPatch, an implantable, low‐swelling amphiphilic hydrogel system containing dexamethasone‐PLGA microparticles, is developed and characterized for sustained local steroid release to reduce postoperative inflammation in tight surgical spaces. DexaPatch significantly reduces postoperative edema and fibrosis in a rabbit model of anterior spinal surgery,
Stephen W. Linderman+6 more
wiley +1 more source
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum+28 more
wiley +1 more source
Hyperalgesia and Reduced Offset Analgesia During Spinal Anesthesia
Elske Sitsen, Monique van Velzen, Mischa de Rover, Albert Dahan, Marieke Niesters Department of Anesthesiology, Leiden University Medical Center, Leiden, RC 2300, the NetherlandsCorrespondence: Marieke NiestersDepartment of Anesthesiology, Leiden ...
Sitsen E+4 more
doaj
Effect of ramosetron on shivering during spinal anesthesia [PDF]
BackgroundShivering associated with spinal anesthesia is uncomfortable and may interfere with monitoring. The aim of this study is to evaluate the effect of ramosetron, a serotonin-3 receptor antagonist, on the prevention of shivering during spinal ...
Min Soo Kim+4 more
doaj +1 more source
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez+14 more
wiley +1 more source
This study evaluated the safety and efficacy of spinal anesthesia as an alternative to general anesthesia in single-port access (SPA) laparoscopic adnexal surgeries. 110 patients were recruited and, after propensity score matching, 63 (general anesthesia:
Kyung Jin Eoh+7 more
doaj +1 more source
Spinal anesthesia; the Holy Grail? [PDF]
Marieke Voet, Cornelis SlagtDepartment of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, The NetherlandsAfter reading the paper recently published in Local and Regional Anesthesia by Whitaker et al:1 “Spinal anesthesia after intraoperative cardiac arrest during general anesthesia in an infant,” we ...
Marieke Voet, Cornelis Slagt
openaire +7 more sources
Effect of oral tizanidine on prolongation of intrathecal lidocaine [PDF]
Objective: In order to prolong the duration of intrathecal lidocaine, various drugs are used along with it. Due to the promising effects of tizanidine on central nervous system, it can be assumed that tizanidine can have a positive effect on increasing
Arman Taheri1 , Morteza Hashemian2 , Mehrdad Noroozi2* , Mohamma,
core
Lumbar puncture for the generalist [PDF]
The safe and successful performance of a lumbar puncture demands a working and yet specific knowledge as well as competency in performance. This review aims to aid understanding of the knowledge framework, the pitfalls and complications of lumbar ...
Abrahams, Peter H.+3 more
core +2 more sources