Results 91 to 100 of about 749,166 (312)

Metabolic profile of injured human spinal cord determined using surface microdialysis. [PDF]

, 2016
The management of patients having traumatic spinal cord injury (TSCI) would benefit from understanding and monitoring of spinal cord metabolic states. We hypothesized that the metabolism of the injured spinal cord could be visualized using Kohonen self ...
Awad, Bethea, Cozzens, Cripps, Fehlings, Hutchinson, Kohonen, Nelson, Phang, Phang, Phang, Timofeev, Werndle, Werndle   +13 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Exploring positive adjustment in people with spinal cord injury. [PDF]

, 2013
This study explored adjustment in people with spinal cord injury; data from four focus groups are presented. Thematic analysis revealed four themes, managing goals and expectations, comparison with others, feeling useful and acceptance, showing ...
Burridge, J., Dibb, B., Donovan-Hall, M., Ellis-Hill, Caroline, Rushton, D.   +4 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Microdialysis to optimize cord perfusion and drug delivery in spinal cord injury. [PDF]

, 2016
OBJECTIVE: There is lack of monitoring from the injury site to guide management of patients with acute traumatic spinal cord injury. Here we describe a bedside microdialysis monitoring technique for optimizing spinal cord perfusion and drug delivery at ...
Abrahamsson, Abrahamsson, Balis, Bernards, Bracken, Bracken, Carpenter, Casha, Dahyot-Fizelier, Fehlings, Fehlings, Frasca, Hutchinson, Hutchinson, Inoue, Kitagawa, Kobayakawa, Lee, Okon, Papadopoulos, Phang, Phang, Phang, Phang, Plock, Quan, Saadoun, Saadoun, Shannon, Timofeev, Vandenabeele, Varsos, Walters, Werndle, Werndle, Werndle   +35 more
core   +1 more source

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Test–retest reliability of intra-epidermal electrically evoked potentials in comparison with other modalities and across stimulation intensities

Scientific Reports
Intra-epidermal electrically evoked potentials (IEEPs) might represent a promising method for an improved characterization of certain spinal pathologies. Before successful clinical implementation, investigating IEEPs reliability is a prerequisite.
Sara U. Júlio, Pascale Rüegge, Miriam Schneuwly, Kevin Hong, Michèle Hubli, Martin Schubert   +5 more
doaj   +1 more source

Early Decompression (<8h) versus Delayed Surgical Management Improves Functional Outcome after Traumatic Cervical Spinal Cord Injury

Global Spine Journal, 2016
Introduction Traumatic cervical spinal cord injury affects the individual in a multi-faceted way. Early decompression of the spinal canal is recommended. The optimal time point for this intervention has been under debate for decades.
Lukas Grassner, Christof Wutte, Barbara Klein, Orpheus Mach, Silvie Riesner, Stefanie Panzer, Matthias Vogel, Florian Högel, Volker Bühren, Martin Strowitzki, Doris Maier, Jan Vastmans   +11 more
doaj   +1 more source

Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis. [PDF]

, 2019
Epidural electrical stimulation (EES) of the spinal cord has been shown to restore function after spinal cord injury (SCI). Characterization of EES-evoked motor responses has provided a basic understanding of spinal sensorimotor network activity related ...
Beck, Lisa A, Brown, Desmond A, Calvert, Jonathan S, Edgerton, V Reggie, Gerasimenko, Yury P, Gill, Megan L, Grahn, Peter J, Lavrov, Igor A, Lee, Kendall H, Linde, Margaux B, Lopez, Cesar, Sayenko, Dimitry G, Strommen, Jeffrey A, Van Straaten, Meegan G, Veith, Daniel D, Zhao, Kristin D   +15 more
core  

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source