Results 71 to 80 of about 531,097 (305)

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury. [PDF]

, 2019
Neural progenitor cells (NPCs) transplanted into sites of spinal cord injury (SCI) extend large numbers of axons into the caudal host spinal cord. We determined the precise locations of neurons in the graft that extend axons into the caudal host spinal ...
Anil, Selin, Dobkins, Gabriel, Ferguson, Adam R, Gomes-Leal, Walace, Graham, Lori, Huie, J Russell, Lu, Paul, Tuszynski, Mark   +7 more
core  

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Beyond treatment of chronic pain: a scoping review about epidural electrical spinal cord stimulation to restore sensorimotor and autonomic function after spinal cord injury

Neurological Research and Practice, 2023
Epidural electrical epinal cord stimulation (ESCS) is an established therapeutic option in various chronic pain conditions. In the last decade, proof-of-concept studies have demonstrated that ESCS in combination with task-oriented rehabilitative ...
Antonia Luz, Rüdiger Rupp, Rezvan Ahmadi, Norbert Weidner   +3 more
doaj   +1 more source

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog [PDF]

, 2014
Chronic spinal cord dysfunction occurs in dogs as a consequence of diverse aetiologies, including long-standing spinal cord compression and insidious neurodegenerative conditions. One such neurodegenerative condition is canine degenerative myelopathy (DM)
A Brodbelt, A Felbecker, AM Lidstrom, AM Lidstrom, AM Nilselid, B Szoor, C Sihlbom, C Wang, DR Averill, EM Schrijvers, FA Wininger, GB Cherubini, GD Shelton, H Reiber, H Satoh, H Tumani, Intan N. F. Shafie, IR Griffiths, Jacques Penderis, JR Coates, JW Harvey, K Al-Saktawi, K Sasaki, L Klimaschewski, M Calero, MA Stoodley, Mark McLaughlin, Mary Ann A. Lim, O Cordero-Llana, P Montague, P Narayan, PA March, Pamela E. J. Johnston, Paul Montague, PEJ Johnston, Richard Burchmore, RP Grewal, SE Jones, T Awano, Thomas J. Anderson   +39 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Mediolateral damping of an overhead body weight support system assists stability during treadmill walking

Journal of NeuroEngineering and Rehabilitation, 2020
Background Body weight support systems with three or more degrees of freedom (3-DoF) are permissive and safe environments that provide unloading and allow unrestricted movement in any direction.
M. Bannwart, S. L. Bayer, N. König Ignasiak, M. Bolliger, G. Rauter, C. A. Easthope   +5 more
doaj   +1 more source

Microdialysis to optimize cord perfusion and drug delivery in spinal cord injury. [PDF]

, 2016
OBJECTIVE: There is lack of monitoring from the injury site to guide management of patients with acute traumatic spinal cord injury. Here we describe a bedside microdialysis monitoring technique for optimizing spinal cord perfusion and drug delivery at ...
Abrahamsson, Abrahamsson, Balis, Bernards, Bracken, Bracken, Carpenter, Casha, Dahyot-Fizelier, Fehlings, Fehlings, Frasca, Hutchinson, Hutchinson, Inoue, Kitagawa, Kobayakawa, Lee, Okon, Papadopoulos, Phang, Phang, Phang, Phang, Plock, Quan, Saadoun, Saadoun, Shannon, Timofeev, Vandenabeele, Varsos, Walters, Werndle, Werndle, Werndle   +35 more
core   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Trainer in a pocket - proof-of-concept of mobile, real-time, foot kinematics feedback for gait pattern normalization in individuals after stroke, incomplete spinal cord injury and elderly patients

Journal of NeuroEngineering and Rehabilitation, 2018
Background Walking disabilities negatively affect inclusion in society and quality of life and increase the risk for secondary complications. It has been shown that external feedback applied by therapists and/or robotic training devices enables ...
Daniel Schließmann, Maria Nisser, Christian Schuld, Till Gladow, Steffen Derlien, Laura Heutehaus, Norbert Weidner, Ulrich Smolenski, Rüdiger Rupp   +8 more
doaj   +1 more source