Results 111 to 120 of about 509,584 (363)

Enhancing Grasping Function with a Thermoresponsive Ionogel Adhesive Glove for Patients with Rheumatic Diseases

open access: yesAdvanced Science, EarlyView.
This study presents a novel portable grasp‐assist glove, weighing only 47 g. The glove integrates smart adhesive pads and a hands‐free control interface based on IMU, designed to aid rheumatic patients with impaired hand function. The system enables switchable adhesion with independent control and detection of user release intent.
Shiqiang Wang   +11 more
wiley   +1 more source

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

open access: yesAdvanced Science, EarlyView.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman   +11 more
wiley   +1 more source

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

open access: yesScience Translational Medicine, 2019
Environmental enrichment induces activity-dependent histone acetylation via a druggable mechanism to promote recovery after spinal cord injury. An epigenetic mechanism for regenerating axons Functional recovery after spinal cord injury (SCI) is limited ...
T. Hutson   +23 more
semanticscholar   +1 more source

The Ballistic Pressure Wave Theory of Handgun Bullet Incapacitation [PDF]

open access: yesarXiv, 2008
This paper presents a summary of seven distinct chains of evidence, which, taken together, provide compelling support for the theory that a ballistic pressure wave radiating outward from the penetrating projectile can contribute to wounding and incapacitating effects of handgun bullets.
arxiv  

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun   +10 more
wiley   +1 more source

Circadian modulation of microglial physiological processes and immune responses

open access: yesGlia, Volume 71, Issue 2, Page 155-167, February 2023., 2023
Main Points Microglia are rhythmic cells with an oscillatory expression in clock genes, cytokines, and other microglial markers. Microglial circadian rhythms determine their physiological function and immune responses. Abstract Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against
Mara A. Guzmán‐Ruiz   +11 more
wiley   +1 more source

Height prediction of individuals with osteogenesis imperfecta by machine learning

open access: yesOrphanet Journal of Rare Diseases
Background Osteogenesis imperfecta (OI) is a genetic disorder characterized by low bone mass, bone fragility and short stature. There is a significant gap in knowledge regarding the growth patterns across different types of OI, and the prediction of ...
Hongjiang Yang   +7 more
doaj   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang   +9 more
wiley   +1 more source

Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia

open access: yesGlia, Volume 71, Issue 2, Page 334-349, February 2023., 2023
Main Points Defined a pig microglial transcriptome signature comprising 239 genes. Demonstrated regional variance in the pig microglial transcriptome across the brain. Revealed similarity of pig microglial gene expression to that of human and mouse microglia.
Barbara B. Shih   +8 more
wiley   +1 more source

Utilisation de la substitution sensorielle par électro-stimulation linguale pour la prévention des escarres chez les paraplégiques. Etude préliminaire [PDF]

open access: yesL'escarre 30 (2006) 24-37, 2006
Pressure ulcers are recognized as a major health issue in individuals with spinal cord injuries and new approaches to prevent this pathology are necessary. An innovative health strategy is being developed through the use of computer and sensory substitution via the tongue in order to compensate for the sensory loss in the buttock area for individuals ...
arxiv  

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