Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co-ordination after spinal cord injury [PDF]
, 2017 Autologous cell transplantation is a promising strategy for repair of the injured spinal cord. Here we have studied the repair potential of mesenchymal stromal cells isolated from the human olfactory mucosa after transplantation into a rodent model of ...
Barnett, Susan Carol +5 more
core +1 more source
Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain
Advanced Materials, EarlyView.A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng +11 more
wiley +1 more source
Investigation of Photoplethysmographic Changes using a Static Compression Model of Spinal Cord Injury [PDF]
, 2009 Little is known about cell death in spinal cord tissue following compression injury, despite compression being a key component of spinal injuries.
George, K. +3 more
core +1 more source
Bioengineered Models of Nerve Regeneration
Advanced Materials Technologies, EarlyView.Bioengineered nerve regeneration platforms ranging from patterned cell cultures and hydrogels to fibrous scaffolds and microfluidic systems are reviewed, highlighting the complex cellular and biochemical environments essential for nerve repair. Challenges associated with these platforms, such as balancing complexity with throughput and the need for ...
Madalynn Jade Thompson +1 more
wiley +1 more source
Neurorehabilitation and Neural Repair, 2019 Background. Epidural spinal electrical stimulation at the lumbar spinal level evokes rhythmic muscle activation of lower-limb antagonists, attributed to the central pattern generator.
Álvaro Megía García +4 more
semanticscholar +1 more source
Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts. [PDF]
, 2019 Neural progenitor cell grafts form new relays across sites of spinal cord injury (SCI). Using a panel of neuronal markers, we demonstrate that spinal neural progenitor grafts to sites of rodent SCI adopt diverse spinal motor and sensory interneuronal ...
Kadoya, Ken +4 more
core
Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction [PDF]
, 2018 The brain communicates with the spinal cord through numerous axon tracts that arise from discrete nuclei, transmit distinct functions, and often collateralize to facilitate the coordination of descending commands.
Blackmore, Murray G. +4 more
core +2 more sources
Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening
Advanced Materials Technologies, EarlyView.This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló +5 more
wiley +1 more source
Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies
Stem cell research & therapeutics, 2019 The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons.
Anwen Shao +3 more
semanticscholar +1 more source
Clinical Challenges in Soft Robotics
Advanced Robotics Research, EarlyView.This review explores the exciting field of soft robots for medical applications. It delves into the critical challenges facing their development, including material selection, cytotoxicity, and locomotion limitations. The review then examines promising avenues for overcoming these hurdles and achieving clinical translation.
Kailas Mahipal Malappuram +3 more
wiley +1 more source