Results 141 to 150 of about 710,546 (383)

A Brain–Spinal Interface Alleviating Gait Deficits after Spinal Cord Injury in Primates

Nature, 2016
Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain–computer interfaces have directly linked cortical activity to electrical stimulation of muscles, and have thus ...
M. Capogrosso, T. Milekovic, D. Borton, Fabien B. Wagner, E. M. Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jérôme Gandar, Q. Barraud, David Xing, Elodie Rey, S. Duis, Jianzhong Yang, W. K. D. Ko, Qin Li, P. Detemple, T. Denison, S. Micera, E. Bézard, J. Bloch, G. Courtine   +20 more
semanticscholar   +1 more source

Spinal Cord Stimulation for Spinal Cord Injury

, 2023
Spinal cord injury is a medically complex and life-disrupting condition, associated with very high mortality rates (early death rates after admission range from 4 to 20%). In addition, it’s complicated subsequent severe disability due to the development of early or late complications.
Emil, Isagulyan,, Valentina, Mikhailova,, Nikita, Ilyinski,   +2 more
openaire   +2 more sources

MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study [PDF]

, 2013
BACKGROUND: In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their relation to ...
Altmann, DR, Ashburner, J, Curt, A, Freund, P, Friston, K, Sutter, R, Thompson, A, Weiskopf, N, Wolf, K   +8 more
core   +2 more sources

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

The Distribution of Paralysis and Anaesthesia in Injuries of the Cervical Region of the Spinal Cord [PDF]

, 1888
William Thorburn
openalex   +1 more source

Role and prospects of regenerative biomaterials in the repair of spinal cord injury

Neural Regeneration Research, 2019
Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions.
Shuo Liu, Yuanyuan Xie, Bin Wang
semanticscholar   +1 more source

Optical measurement of blood flow changes in spinal cord injury [PDF]

, 2010
Little is known about cell death in spinal cord tissue following compression injury, despite compression being a key component of spinal injuries.
Allen J, Castro-Moure F, Crowe M J, J P Phillips, K J George, P A Kyriacou, Phillips J P, Phillips J P, R M Langford   +8 more
core   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Exploring the relationship of clinical walking tests with 8-months inertial measurement unit (IMU)-based real world mobility tracking in stroke and spinal cord injury survivors

Neurological Research and Practice
Background Mobility is crucial for participation and quality of life in individuals with sensorimotor impairments, yet scientific evidence on its course in real-world settings is limited.
Andreas Hug, Tamara Spingler, Viola Pleines, Laura Heutehaus, Mircea Ariel Schoenfeld, Björn Hauptmann, Jürgen Moosburger, Roland Thietje, Oliver Pade, Wolfgang Rössy, Klaus Stecker, Jochen Klucken, Tiziana Daniel, Michel Wensing, Cornelia Hensel, Rüdiger Rupp, Norbert Weidner   +16 more
doaj   +1 more source

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Advanced Science, EarlyView.
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier   +24 more
wiley   +1 more source