Results 81 to 90 of about 723,074 (354)

Recovery of Over‐Ground Walking after Chronic Motor Complete Spinal Cord Injury

New England Journal of Medicine, 2018
Persons with motor complete spinal cord injury, signifying no voluntary movement or sphincter function below the level of injury but including retention of some sensation, do not recover independent walking. We tested intense locomotor treadmill training
C. Angeli, M. Boakye, Rebekah A Morton, Justin Vogt, Kristin Benton, Yangsheng Chen, Christie K. Ferreira, S. Harkema   +7 more
semanticscholar   +1 more source

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

Brain : a journal of neurology, 2020
In spinal cord injury, the initial mechanical insult may be followed by progressive cord atrophy and neurodegeneration. Zrzavy et al. characterize innate and adaptive inflammatory responses in human spinal cord injury, and show that oxidative injury is a
T. Zrzavy, C. Schwaiger, I. Wimmer, T. Berger, J. Bauer, O. Butovsky, J. Schwab, H. Lassmann, R. Höftberger   +8 more
semanticscholar   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

Journal of Neuroinflammation, 2022
Background Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal cord injury (SCI).
Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng   +14 more
doaj   +1 more source

LRP1 Deficiency Promotes Mitostasis in Response to Oxidative Stress: Implications for Mitochondrial Targeting after Traumatic Brain Injury

Cells, 2023
The brain undergoes oxidative stress and mitochondrial dysfunction following physiological insults such as Traumatic brain injury (TBI), ischemia-reperfusion, and stroke.
Gopal V. Velmurugan, W. Brad Hubbard, Paresh Prajapati, Hemendra J. Vekaria, Samir P. Patel, Alexander G. Rabchevsky, Patrick G. Sullivan   +6 more
doaj   +1 more source

Metabolic profile of injured human spinal cord determined using surface microdialysis. [PDF]

, 2016
The management of patients having traumatic spinal cord injury (TSCI) would benefit from understanding and monitoring of spinal cord metabolic states. We hypothesized that the metabolism of the injured spinal cord could be visualized using Kohonen self ...
Awad, Bethea, Cozzens, Cripps, Fehlings, Hutchinson, Kohonen, Nelson, Phang, Phang, Phang, Timofeev, Werndle, Werndle   +13 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Mapping reticulospinal drive across various muscles of the upper and lower extremities

Experimental Physiology
The reticulospinal (RS) system is a fundamental descending pathway involved in human movement control. However, the relative strength of RS projections across different muscles and its specific contributions to distinct movements are poorly understood ...
Antonia Maria Eilfort, Lennart Carlson Neumann, Linard Filli   +2 more
doaj   +1 more source

Correlation Analysis Between Magnetic Resonance Imaging-Based Anatomical Assessment and Behavioral Outcome in a Rat Contusion Model of Chronic Thoracic Spinal Cord Injury

Frontiers in Neuroscience, 2022
Although plenty of evidences from preclinical studies have led to potential treatments for patients with spinal cord injury (SCI), the failure to translate promising preclinical findings into clinical advances has long puzzled researchers.
Cong Xing, Cong Xing, Cong Xing, Zeyu Jia, Zeyu Jia, Zeyu Jia, Haodong Qu, Haodong Qu, Haodong Qu, Song Liu, Song Liu, Song Liu, Wang Jiang, Hao Zhong, Hao Zhong, Hao Zhong, Mi Zhou, Mi Zhou, Mi Zhou, Shibo Zhu, Shibo Zhu, Shibo Zhu, Guangzhi Ning, Guangzhi Ning, Guangzhi Ning, Shiqing Feng, Shiqing Feng, Shiqing Feng   +27 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source