Results 71 to 80 of about 723,074 (354)

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice

Theranostics, 2020
Neuropsychological deficits, including impairments in learning and memory, occur after spinal cord injury (SCI). In experimental SCI models, we and others have reported that such changes reflect sustained microglia activation in the brain that is ...
Yun Li, Rodney M. Ritzel, Niaz Z. Khan, Tuoxin Cao, Junyun He, Zhuofan Lei, Jessica J. Matyas, B. Sabirzhanov, Simon Liu, Hui Li, B. Stoica, David J. Loane, A. Faden, Junfang Wu   +13 more
semanticscholar   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction [PDF]

, 2018
The brain communicates with the spinal cord through numerous axon tracts that arise from discrete nuclei, transmit distinct functions, and often collateralize to facilitate the coordination of descending commands.
Blackmore, Murray G., Maunze, Brian, Tsoulfas, Pantelis, Wang, Yunfang, Wang, Zimei   +4 more
core   +2 more sources

Treatment of spinal cord injury with mesenchymal stem cells

Cell & Bioscience, 2020
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.
L. L. Liau, Q. H. Looi, Wui Chuen Chia, Thayaalini Subramaniam, M. Ng, J. Law   +5 more
semanticscholar   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

A case study of percutaneous epidural stimulation to enable motor control in two men after spinal cord injury

Nature Communications, 2023
Two persons with chronic motor complete spinal cord injury (SCI) were implanted with percutaneous spinal cord epidural stimulation (SCES) leads to enable motor control below the injury level (NCT04782947).
Ashraf S. Gorgey, Robert Trainer, Tommy W. Sutor, Jacob A. Goldsmith, Ahmed Alazzam, Lance L. Goetz, Denise Lester, Timothy D. Lavis   +7 more
doaj   +1 more source

Long-term change in respiratory function following spinal cord injury. [PDF]

, 2016
STUDY DESIGN: Retrospective study. OBJECTIVES: To model the effect of time since injury on longitudinal respiratory function measures in spinal cord injured-individuals and to investigate the effect of patient characteristics.
Berlowitz, DJ, Graco, M, Peters, AE, Schembri, R, Thijssen, DHJ, van Silfhout, L   +5 more
core   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Spinal Cord Epidural Stimulation Improves Lower Spine Sitting Posture Following Severe Cervical Spinal Cord Injury

Bioengineering, 2023
Cervical spinal cord injury (SCI) leads to impaired trunk motor control, negatively impacting the performance of activities of daily living in the affected individuals.
Kundan Joshi, Enrico Rejc, Beatrice Ugiliweneza, Susan J. Harkema, Claudia A. Angeli   +4 more
doaj   +1 more source

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. [PDF]

, 2010
Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal ...
Beattie, Michael S, Bresnahan, Jacqueline C, Brock, John H, Courtine, Gregoire, Edgerton, V Reggie, Ferguson, Adam R, Havton, Leif A, Jindrich, Devin L, Miller, Darren M, Nout, Yvette S, Rosenzweig, Ephron S, Roy, Roland R, Strand, Sarah C, Tuszynski, Mark H   +13 more
core