Results 141 to 150 of about 316,544 (362)

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source

Mielopatia compressiva por lipoma de células fusiformes infiltrativo em cão Compressive myelopathy by infiltrative spindle cell lipoma in a dog

Ciência Rural, 2013
Relata-se um caso de lipoma de células fusiformes infiltrativo diagnosticado em cadela com sinais neurológicos de ataxia proprioceptiva, reação postural ausente no membro pélvico direito, paraparesia fracamente ambulatória e dor à palpação sobre as ...
Rosmarini Passos dos Santos, Glaucia Denise Kommers, Ricardo Barbosa Lucena, Diego Vilibaldo Beckmann, Graciane Aiello, Cristiano Gomes, Angel Ripplinger, Alexandre Mazzanti   +7 more
doaj  

Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup

Case Reports in Surgery, 2013
Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium.
Ali S. Shirzadi, Doniel G. Drazin, Allison S. Strickland, Serguei I. Bannykh, J. Patrick Johnson   +4 more
doaj   +1 more source

Jefferson Alumni Bulletin – Volume XXX, Number 2, Winter 1981 [PDF]

, 1981
Jefferson Alumni Bulletin – Volume XXX, Number 2, Winter 1981 Diverse specialties harmonize, Page 2 The Navstar: a Pre-Columbian crossing, Page 8 President Cleveland’s lesion: new evidence uncovered, Page 15 Class notes, Page ...

core   +1 more source

Renal Cell Carcinoma presented with An Intramedullary Spinal Cord Metastasis : A Case Report

, 2016
Intramedullary spinal cord metastasis is one of the rare manifestations of systemic neoplasm causing diagnostic dilemma. Here we report a case of metastatic renal cell carcinoma presented initially as spinal cord lesion.
R. Islam, Tanbin Rahman, R. Habib, Aminur Rahman, N. B. Bhowmik, Amirul Haque   +5 more
semanticscholar   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord [PDF]

, 2020
Elisa K. Liu, Joshua S. Silverman, Erik P. Sulman   +2 more
openalex   +1 more source

Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal‐Amplifying Fluidic Biomimetic Hydrogel

Advanced Science, EarlyView.
An in situ moldable GelSSO/PDA@SDF hydrogel functions as a chronotaxic signal‐amplifying biomimetic niche to restore regenerative failure in diabetic cranial defects. By sequentially releasing SDF‐1α‐loaded PDA nanoparticles and osteoinductive oligodeoxynucleotides, it orchestrates immunomodulation, progenitor recruitment, angiogenesis, and ...
Yingji Mao, Yu Chen, Runlin Fan, Pengzhen Zhuang, Hongbo Zhang, Pinghui Zhou   +5 more
wiley   +1 more source