Results 101 to 110 of about 54,777 (293)

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. [PDF]

, 2002
OBJECTIVE: The aim of this study is to re-appraise paediatric leptomeningeal disseminated spinal low-grade neoplasms putting forward the hypothesis that these tumours may represent a possible distinctive clinico-pathological entity.
PERILONGO, GIORGIO, BATTISTELLA, PIER ANTONIO, CALDERONE M, BURNELLI R, BISAGLIA L, GARDIMAN M, GIANGASPERO F., RIGOBELLO L   +7 more
core  

Tumors of the central nervous system, volume 6: Spinal tumors (part 1) [PDF]

, 2012
With tens of thousands of new CNS tumor cases each year in the US alone, this Book Series is a vital resource for any medical professional encountering brain and CNS neoplasms in their work.
Hayat, M. A.Eric
core   +1 more source

Intramedullary Glioblastoma as One of Multiple Radiation-Induced Neoplasms

Case Reports in Oncology
Introduction: Intramedullary glioblastoma is a rare entity comprising 1.4–9% of spinal gliomas. Spinal cord radiation-induced gliomas are unique, with only 13 cases reported to date.
Kacper Koczyk, Arkadiusz Nowak, Marcin M. Machnicki, Łukasz Zdzisław Michałowski, Edyta Maj, Tomasz Stoklosa, Przemysław Kunert   +6 more
doaj   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Spinal cord compression secondary to spinal extradural myeloid sarcoma in acute myeloid leukaemia: A case report and literature review

Brain Disorders
Introduction: Myeloid sarcoma (MS) is a rare pathology that includes immature myeloid progenitor cells and is an infrequent form of acute myeloid leukemia (AML). It may occur de novo or be associated with other myeloproliferative disorders.
Prakash Palave, Nitin Naikwade, Ashvini Mahamuni, Egemen Gok, Kivanc Yangi, Ismail Bozkurt, Bipin Chaurasia   +6 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Spinal neurologic complications of systemic solid neoplasms [PDF]

, 2005
Spinal cord dysfunctions represent a major cause of morbidity and suffering in cancer. There are four main manifestations of metastatic epidural spinal cord compression: pain, motor loss, sensory loss, and autonomic dysfunction.
Jandolo B., Collice M., Brioschi A., Bacigaluppi S., Riva M.   +4 more
core  

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Epidemiological features of spinal intradural tumors, a single-center clinical study in Beijing, China

BMC Musculoskeletal Disorders
Background Spinal intradural tumors are rare and heterogeneous in histological type, aggressiveness, and symptomatology, and there is a lack of data about them. This study investigated the epidemiological features of spinal intradural tumors.
Longqi Liu, Liang Shi, Yibing Su, Keda Wang, Hanbin Wang   +4 more
doaj   +1 more source