Results 81 to 90 of about 64,642 (341)

Spinal Cord Malformation Containing a Papillary Neoplasm

The FASEB Journal, 2008
A 36‐year‐old man had lower back pain for over one year. MRI revealed an intradural mass with a cystic component, inferior to the spinal cord at L2‐L3, with no bony abnormality of the spine. At surgery, the mass was entirely intradural, inferior to the spinal cord and intimately attached to nerve roots of the cauda equina.
Leroy R. Sharer, Robert F. Heary, Eun‐Sook Cho, Douglas C. Miller   +3 more
openaire   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Giant cell tumor of the thoracic spine: An unusual cause for spinal cord compression

Radiology Case Reports
Giant cell tumors (GCTs) of bone are uncommon neoplasms, typically located in the metaphysis of long bones, with rare occurrences in the spine, especially in the thoracic region.
Ghassen Gader, Fatma Ben Attig, Wiem Mansour, Abdelhafidh Slimane, Malek Bourgou, Mohamed Badri, Ihsèn Zammel   +6 more
doaj   +1 more source

Incidence and Outcomes of Acute Implant Extrusion Following Anterior Cervical Spine Surgery. [PDF]

, 2017
STUDY DESIGN: Multi-institutional retrospective case series of 8887 patients who underwent anterior cervical spine surgery. OBJECTIVE: Anterior decompression from discectomy or corpectomy is not without risk.
Arnold, Paul M., Bumpass, David B., Bydon, Mohamad, Corriveau, Mark, Fehlings, Michael G., Fogelson, Jeremy L., Gokaslan, Ziya, Hart, Robert A., Hilibrand, Alan S., Lee, Sungho, Massicotte, Eric M., Mroz, Thomas E., Nassr, Ahmad, Pace, Jonathan, Riew, K. Daniel, Smith, Gabriel A., Steinmetz, Michael P.   +16 more
core   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Infiltrating Tumor versus Demyelination Disorders: Case Study of Two Adults

Indian Journal of Neurosurgery
Long-segment intramedullary spinal cord lesions pose a unique diagnostic and therapeutic dilemma from a neurosurgical perspective. For the operating surgeon, the central challenge lies in distinguishing infiltrative intramedullary tumors from ...
Harsh Rajeshbhai Patel, Preeti Singh, Abhaya Kumar   +2 more
doaj   +1 more source

Bifocal extra- and intradural melanocytoma of the spine: case report and literature review [PDF]

, 2018
Background: Spinal melanocytoma is one of the most infrequent space-occupying lesions of the central nervous system. To the best of our knowledge, this is the first report of primary bifocal intradural melanocytoma of heterogenous pathological grade to ...
Foit, Niels, Krayenbühl, Niklaus, Neidert, Marian, Rushing, Elisabeth, Woernle, Christoph   +4 more
core  

Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants. [PDF]

, 2020
The Genotype-Tissue Expression (GTEx) resource has provided insights into the regulatory impact of genetic variation on gene expression across human tissues; however, thus far has not considered how variation acts at the resolution of the different cell ...
D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Donovan, Margaret KR, Frazer, Kelly A   +3 more
core  

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source