Results 251 to 260 of about 63,554 (339)

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Encephalic fibrosarcoma in a dog. [PDF]

J Vet Diagn Invest
Crawford MJ, Demeter EA, Armién AG, Radisic R, Rissi DR.   +4 more
europepmc   +1 more source

Acute neurologic presentation of a 2‐year‐old standardbred colt with multicentric diffuse large B cell lymphoma

Equine Veterinary Education, EarlyView.
Summary Lymphoma in horses is uncommon and rarely diagnosed as a cause of ataxia. This case report describes a 2‐year‐old Standardbred cryptorchid colt who presented with acute onset of grade 3–4/5 spinal ataxia in all four limbs, with the hindlimbs more severely affected than forelimbs and severe proprioceptive deficits.
K. MacMillan, J. Burns, E. John, M. Buote   +3 more
wiley   +1 more source

Single Potential Analysis of Cavernous Electric Activity in Spinal Cord Injury Patients [PDF]

, 1994
Höppner, C., Jonas, Udo, Sauerwein, D., Stief, Christian Georg   +3 more
core  

Silent pressure: Unveiling spinal lymphoma in horses and its parallels to other species

Equine Veterinary Education, EarlyView.
Summary Though the nervous system is an uncommon location for lymphoma, the disease should remain a differential diagnosis in some cases of ataxia in equids. Diagnosis of lymphoma can be challenging, although a combination of cytology, histopathology and immunophenotyping can aid in definitive diagnosis and therefore more accurately guide treatment and
H. E. Taylor, D. Luethy
wiley   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Intraoperative Ultrasound in the Management of Rare Lesions Involving the Intradural Extramedullary Spinal Compartment: A Quick, but Effective Helping Hand to Define the Optimal Surgical Strategy. [PDF]

Cancers (Basel)
Pesce A, Di Carlo L, Palmieri M, Novegno F, Iaquinandi A, Denaro L, Armocida D, Santoro A, Salvati M, Ius T, Frati A.   +10 more
europepmc   +1 more source

石灰化を伴った脊髄腫瘍2例 [PDF]

, 1989
IIDA, HIROKAZU, KASHIWAGI, NAOYA, SHIKATA, JITSUHIKO, YAMAMURO, TAKAO   +3 more
core  

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Initial management and disposition of metastatic spinal cord compression in the emergency department: a review of the literature. [PDF]

Ann Med
Singer E, Elsayem A, Nassif T, Rodriguez C, Zoghbi M, Dagher J, Yammine N, Kamal M, Cruz Carreras MT, Vu T, Qdaisat A, Yeung SJ, Chaftari P.   +12 more
europepmc   +1 more source