Results 51 to 60 of about 532,221 (295)

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Role of chondroitin sulfate proteoglycans (CSPGs) in synaptic plasticity and neurotransmission in mammalian spinal cord. [PDF]

, 2009
Chronic unilateral hemisection (HX) of the adult rat spinal cord diminishes conduction through intact fibers in the ventrolateral funiculus (VLF) contralateral to HX.
Victor L. Arvanian, Guillermo Garcia-Alias, Arsen S. Hunanyan, Joel M. Levine, James W. Fawcett, Lorne M. Mendell   +5 more
core  

Unusual appearance of spontaneous spinal intradural hematoma mimicking a meningioma

Radiology Case Reports
Spontaneous spinal intradural hematoma is uncommon. It can mimic vascular or hemorrhagic neoplasms, as certain imaging features overlap. The distinction between spinal hematoma and neoplasm is crucial for the approach to management and might determine ...
Akeel A. Alali, MD, FRCPC, ABR, Ali H. Alassiri, MD, FRCPC   +1 more
doaj   +1 more source

Postoperative radiation for primary melanoma of the cervical spinal cord in a pregnant patient: A case report & review of the literature

Interdisciplinary Neurosurgery, 2018
Only 1% of melanomas present with isolated involvement of the central nervous system. Primary melanoma of the spinal cord is especially rare. There are only a handful of cases reported and only one reported during pregnancy. The patient was a 27-year-old
Samantha Stubbs, BS, Haris Vakil, BS, Gary D. Lewis, MD, Sarah A. Westergaard, MD, Gerald A. Campbell, MD, PhD, Todd A. Swanson, MD, PhD   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Chronic thoracic hemisection spinal cord injury in adult rats induces a progressive decline in transmission from uninjured fibers to lumbar motoneurons [PDF]

, 2008
Although most spinal cord injuries are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions.
Hunanyan, Arsen, John K. Robinson, Schnell, Lisa, Golshani, Roobeh, Li Lou, Roobeh Golshani, Lou, Li, Robinson, John, Lisa Schnell, Ghosh, Arko, Victor L. Arvanian, Schwab, Martin, Damien D. Pearse, Arvanian, Victor, Arsen Hunanyan, Martin E. Schwab, Arko Ghosh, Mendell, Lorne, James W. Fawcett, Lorne M. Mendell, Pearse, Damien, Fawcett, James   +21 more
core   +1 more source

Central Nervous System Tumors in Guilan, Iran: Epidemiological Features Over 10 Years

Caspian Journal of Neurological Sciences, 2015
Background: Tumors of the central nervous system (CNS) are a heterogeneous group of neoplasms with different prevalence in different sex and age groups and various parts of CNS.
Kourosh Askari, Sara Janeshin, Mehryar Mashouf, Maryam Taherzadeh-Amlashi, Seyed-Mohammad Seyed-Saadat   +4 more
doaj  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing [PDF]

, 2003
One of the most devastating effects of damage to the upper spinal cord is the loss of the ability to breathe; patients suffering these injuries can be kept alive only with assisted ventilation. No known method for repairing these injuries exists.
Raisman, G., Li, Y., Decherchi, P.
core  

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source