Results 91 to 100 of about 517,553 (284)

Patient‐Specific Analysis of Neural Activation During Spinal Cord Stimulation for Pain

Neuromodulation (Malden, Mass.), 2019
Despite the widespread use of spinal cord stimulation (SCS) for chronic pain management, its neuromodulatory effects remain poorly understood. Computational models provide a valuable tool to study SCS and its effects on axonal pathways within the spinal ...
S. Lempka, H. Zander, Carlos J Anaya, A. Wyant, J. Ozinga, A. Machado   +5 more
semanticscholar   +1 more source

Prediction of isometric forces from combined epidural spinal cord and neuromuscular electrical stimulation in the rat lower limb

Scientific Reports
Although epidural spinal cord and muscle stimulation have each been separately used for restoration of movement after spinal cord injury, their combined use has not been widely explored.
Daniel Song, Matthew C. Tresch
doaj   +1 more source

Priming locomotor training with transspinal stimulation in people with spinal cord injury: study protocol of a randomized clinical trial

Trials, 2023
Background The seemingly simple tasks of standing and walking require continuous integration of complex spinal reflex circuits between descending motor commands and ascending sensory inputs. Spinal cord injury greatly impairs standing and walking ability,
Andreas Skiadopoulos, Grace O. Famodimu, Shammah K. Solomon, Parul Agarwal, Noam Y. Harel, Maria Knikou   +5 more
doaj   +1 more source

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury. [PDF]

, 2019
AimThe activation of the TNFR2 receptor is beneficial in several pathologies of the central nervous system, and this study examines whether it can ameliorate the recovery process following spinal cord injury.MethodsEHD2-sc-mTNFR2 , an agonist specific ...
Bethea, John R, Blumenthal, Gary H, Bracchi-Ricard, Valerie, Fischer, Roman, Gerald, Marcus J, Kontermann, Roland E, Moxon, Karen A, Nandakumar, Bharadwaj, Pfizenmaier, Klaus, Ricard, Jerome, Williams, Raushaun   +10 more
core   +2 more sources

Closed-Loop Spinal Cord Stimulation in Chronic Pain Management: Mechanisms, Clinical Evidence, and Emerging Perspectives

Biomedicines
Background: Chronic pain remains a major clinical challenge, which is often resistant to conventional treatments. Spinal cord stimulation has been used for decades to manage refractory pain, traditionally relying on open-loop systems with fixed-output ...
Nicholas Mangano, Andrew Torpey, Catherine Devitt, George A. Wen, Christopher Doh, Abhishek Gupta   +5 more
doaj   +1 more source

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling

Frontiers in Human Neuroscience, 2017
Spinal cord excitability, as assessed by modulation of Hoffmann (H-) reflexes, is reduced with fatiguing isometric contractions. Furthermore, spinal cord excitability is reduced during non-fatiguing arm and leg cycling.
Gregory E. P. Pearcey, Gregory E. P. Pearcey, Gregory E. P. Pearcey, Steven A. Noble, Steven A. Noble, Steven A. Noble, Bridget Munro, E. Paul Zehr, E. Paul Zehr, E. Paul Zehr, E. Paul Zehr   +10 more
doaj   +1 more source

Activation of Long Descending Propriospinal Neurons in Cat Spinal Cord [PDF]

, 1980
Isolated mammalian spinal cord has been shown capable of generating locomotor activity. Propriospinal systems assumed to coordinate fore- and hindlimb activity are poorly understood.
Adams, Robert J., Remmel, Ronald S., Skinner, Robert D.   +2 more
core   +2 more sources

Abdominal functional electrical stimulation to enhance mechanical insufflation-exsufflation [PDF]

, 2015
Context: Respiratory complications, attributed to the build-up of secretions in the airway, are a leading cause of rehospitalisation for the tetraplegic population.
Allan, David B., Gollee, Henrik, McCaughey, Euan J., McLean, Alan N.   +3 more
core   +1 more source

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Nature Protocols, 2018
Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders.
M. Capogrosso, Fabien B. Wagner, Jérôme Gandar, E. M. Moraud, N. Wenger, T. Milekovic, P. Shkorbatova, N. Pavlova, P. Musienko, E. Bézard, J. Bloch, G. Courtine   +11 more
semanticscholar   +1 more source

Effects of guanidine on synaptic transmission in the spinal cord of the frog [PDF]

, 1977
The effects of guanidine on motoneurons of the isolated frog spinal cord were studied by adding the drug to the solution bathing the cord during intracellular recording. Guanidine (5·10–4 M) did not alter the membrane potential of motoneurons.
A. K�hner, B. Katz, E. Gergens, E. H. Lambert, F. Colomo, F. H. Norris, H. Ter�v�inen, J. I. Simpson, K. Koizumi, K. Ricker, M. A. Kamenskaya, M. A. Kamenskaya, M. Otsuka, P. Grafe, R. C. Scaer, S. D. Erulkar, S. J. Oh, U. Sonnhof, U. Sonnhof, W. C. Wiederholt   +19 more
core   +1 more source