Results 131 to 140 of about 230,819 (312)

The Compound Muscle Action Potential as Neurophysiological Marker for Amyotrophic Lateral Sclerosis. [PDF]

, 2016
Objectives: To definite the peripheral nervous involvement in ALS through the repeated use of the compound motor action potential (CMAP) to test the progression of disease, to determine different change of phrenic CMAP and forced vital capacity (FVC) in
CECCANTI , MARCO, FRASCA, VITTORIO, Gori, Maria Cristina, INGHILLERI, Maurizio, ONESTI, EMANUELA, Petrucci, Antonio, Silani, Vincenzo, Tartaglia, Giorgio   +7 more
core  

Why regenerative stem cell medicine progresses slower than expected [PDF]

, 2014
Stem cell research has been acclaimed to revolutionize the future of medicine, and to offer new treatments for previously incurable diseases. Despite years of research, however, the therapeutic potential of stem cell research has not yet been fully ...
Amariglio, Bersenev, Collier, Earls, Feuerstein, Hay, Keating, Keirstead, Keirstead, Knowles, Ledford, Patterson, Rawlins, Rosemann, Sipp, Sleeboom-Faulkner, Wilson   +16 more
core   +1 more source

Spinal Tuberculosis (Pott’s Disease)

Pediatric Neurology Briefs, 2012
Researchers at Great Ormond Street Hospital for Children and Institute of Child Health, London, UK reviewed their experience of childhood spinal tuberculosis (TB) over a 15-year period (1995-2010).
openaire   +4 more sources

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Supervariate Gel Transforms into Various Biominerals in Salt Solutions

Advanced Functional Materials, EarlyView.
It is revealed that common calcium‐based biominerals can form from a stable, non‐toxic ‘supervariate’ gel. This tunable gel selectively yields calcite or hydroxyapatite in carbonate/phosphate solutions, while CaCl₂ facilitates the formation of dihydrate calcium pyrophosphate, which converts to hydroxyapatite upon drying. These findings provide insights
Xinxue Tang, Chong Wang, Yuk‐Tong Cheng, Junda Shen, Yunchen Long, Hongkun Li, Jie Yan, Yang Ren, Xiao Ma, Yufeng Huang, Zhengtao Xu, Jian Lu, Yang Yang Li   +12 more
wiley   +1 more source

Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. [PDF]

, 2018
Reactive astrocytes influence post-injury recovery, repair, and pathogenesis of the mammalian CNS. Much of the regulation of astrocyte reactivity, however, remains to be understood.
Carolino, Krislyn I, Chen, Meifan, Elzière, Lucie, Geoffroy, Cédric G, Goldberg, Mark P, Jin, Yishi, Khai, Vung S, Kong, Xiangmei, Li, Yunbo, Meves, Jessica M, Narang, Aarti, Nguyen, Mallorie T, Steinke, Christopher L, Zheng, Binhai   +13 more
core   +2 more sources

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Ca2+-activated K+channels modulate microglia affecting motor neuron survival in hSOD1G93A mice [PDF]

, 2019
Amyotrophic lateral sclerosis (ALS) is a multifactorial disease characterized by the progressive degeneration of motor neurons (MN) and muscle paralysis. Despite current treatments, patients survive less than 3–5 years after the initial diagnosis.
Cocozza, Germana
core  

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith, Boisgard, Raphael, Brulon, Vincent, Dollé, Frédéric, Dubois, Albertine, Fontyn, Yoann, Maroy, Renaud, Tavitian, Bertrand, Thézé, Benoit   +8 more
core   +2 more sources

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source