Results 41 to 50 of about 329,755 (256)

Advancing the timing of drainage removal: a comprehensive analysis of different drainage removal criteria in patients undergoing short-level lumbar fusion surgery

BMC Surgery
Objective To specifically evaluate the safety and benefit of different drainage removal criteria (50 ml and 100 ml per 24 h) in patients undergoing short-level lumbar fusion surgery.
Peng Cui, Di Han, Xiao-Long Chen, Peng Wang, Shi-Bao Lu   +4 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

The role of supine imaging in assessing failure of pelvic compensation and its impact on surgical outcomes in patients with adult spinal deformity

Journal of Orthopaedic Surgery and Research
Aims This study aims to investigate the impacts of failure of pelvic compensation (FPC), as determined by variations in spinopelvic alignment during the transition from the supine to the upright position, on surgical outcomes in patients with adult ...
Dongfan Wang, Wei Wang, Yu Wang, Chao Kong, Shuaikang Wang, Xiaolong Chen, Shibao Lu   +6 more
doaj   +1 more source

Evaluation of the quality of neurosurgical services using the SERVQUAL method [PDF]

Vojnosanitetski Pregled
Background/Aim. In an era of rapid technological innovation and growing patient expectations, healthcare systems worldwide face the need for continuous improvement in service quality.
Đilvesi Đula, Lasica Nebojša, Golubović Jagoš, Jelača Bojan, Simeunović Nenad, Rakić Slavko   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development and validation of a nomogram to predict the unfavorable outcomes in elderly patients undergoing lumbar fusion surgery for degenerative disease

BMC Surgery
Objective Failure to understand long-term quality of life and functional outcomes hinders effective decision making and prognostication. Therefore, the study aims to predict and analyse the unfavorable outcomes (FOs) in elderly patients undergoing lumbar
Peng Cui, Shuaikang Wang, Haojie Zhang, Peng Wang, Xiaolong Chen, Chao Kong, Shibao Lu   +6 more
doaj   +1 more source

Construction and validation of augmented reality navigation system based on visual tracking guide template in spinal surgery

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To construct an augmented reality (AR) navigation system model based on visual tracking guide template during pedicle screw placement, and to evaluate the application value of the model. Methods A visual tracking guide template was designed and
ZHANG Pei⁃hai, SUN Zhen⁃xing, ZHANG Kai, GUO Yi, CHEN Gang, YANG Xue⁃jun   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Imobilização interna da coluna vertebral lombar com placas de cloreto de polivinila, em cães - parte I: resultados clínico-cirúrgicos Internal immobilization of the lumbar canine spine using polyvinylchloride plates - part I: clinical and surgical results

Ciência Rural, 1997
Utilizando-se 20 cães, com o segmento lombar da coluna vertebral cirurgicamente desestabilizado na junção das vértebras L2-L3, foi testada a eficiência de placas ortopédicas de cloreto de polivinila (PVC) Tigre®, fixadas com parafusos nos corpos ...
Eduardo Alberto Tudury, Cleuza Maria de Faria Rezende, Leonardo Maciel Andrade   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source