Results 11 to 20 of about 88,525 (289)

Spine injections: the rationale for CT guidance [PDF]

, 2023
Back pain is one of the most common medical problems and is associated with high socioeconomic costs. Imaging-guided spinal injections are a minimally invasive method to evaluate where the back pain is originating from, and to treat patients with ...
Reto Sutter, Sutter, Reto, Veronika Zubler, Zubler, Veronika, Sanja Bogdanovic, Bogdanovic, Sanja   +5 more
core   +1 more source

Comparative Clinical Effectiveness of Management Strategies for Sciatica: Systematic Review and Network Meta-Analyses [PDF]

, 2013
Background There are numerous treatment approaches for sciatica. Previous systematic reviews have not compared all these strategies together. Purpose To compare the clinical effectiveness of different treatment strategies for sciatica simultaneously.
Rickard, I, Din, N.U., Ud Din, Nafees, Lewis, Ruth, Nafees Ud Din, Phillips, C.J., Phillips, CJ, Williams, N.H., Deborah Fitzsimmons, Nefyn H. Williams, Ruth A. Lewis, Lewis, R, Phillips, Ceri J., Hendry, Maggie, Burton, K., Williams, Nefyn H, Hendry, M., Din, N, Maggie Hendry, Ceri J. Phillips, Hendry, M, Fitzsimmons, Deborah, Nafees, S, Sutton, A., Fitzsimmons, D., Matar, Hosam E., Ceri Phillips, Rickard, Ian, Rickard, I., Ian Rickard, Alex J. Sutton, Matar, H.E., Kim Burton, Wilkinson, C., Sutton, A.J., Hosam E. Matar, Burton, A. Kim, Sadia Nafees, Clare Wilkinson, Lewis, R.A., Nafees, S., Williams, Nefyn, Burton, Anthony, Matar, HE, Fitzsimmons, D, Wilkinson, Clare, Sutton, Alex, Nafees, Sadia   +47 more
core   +1 more source

Study Protocol- Lumbar Epidural Steroid Injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults [PDF]

, 2012
Background Lumbar spinal stenosis is one of the most common causes of low back pain among older adults and can cause significant disability. Despite its prevalence, treatment of spinal stenosis symptoms remains controversial.
Turner, Judith A, Bauer, Zoya, Nerenz David, Janna L Friedly, Avins, Andrew L, Brian W Bresnahan, Heagerty, Patrick, Friedly, Janna L, Comstock, Bryan, Judith A Turner, Bresnahan Brian W, Sullivan, Sean D, Andrew L Avins, Avins Andrew L, Jarvik Jeffrey G, Patrick Heagerty, Comstock Bryan, Turner Judith A, Richard A Deyo, Deyo, Richard A, Friedly Janna L, Bauer Zoya, Jarvik, Jeffrey G, Nerenz, David, Heagerty Patrick, Nedeljkovic Srdjan S, Srdjan S Nedeljkovic, Bryan Comstock, Deyo Richard A, Sullivan Sean D, Zoya Bauer, Bresnahan, Brian W, Sean D Sullivan, David Nerenz, Jeffrey G Jarvik, Nedeljkovic, Srdjan S   +35 more
core   +1 more source

Spinal Injections for Pain Management [PDF]

Radiology, 2016
Image-guided spinal injection is commonly performed in symptomatic patients to decrease pain severity, confirm the pain generator, and delay or avoid surgery. This article focuses on the radiologist as spine interventionist and addresses the following four topics relevant to the radiologist who performs corticosteroid injections for pain management: (a)
openaire   +2 more sources

Botulinum toxin-A for the treatment of overactive bladder: UK contributions

, 2013
Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ, Panicker, J. N., Fowler, C. J., Dowson, C, Khan, MS, Seth, JH, Dasgupta, P, Dasgupta, P., Panicker, JN, Sahai, A, Dowson, C., Seth, J. H., Khan, M. S., Sahai, Arun   +13 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Effects of inositol 1,4,5-trisphosphate injections into cat spinal motoneurons

, 1990
Inositol 1,4,5-trisphosphate (IP3) was injected iontophoretically into cat spinal motoneurons in pentobarbital-anaesthetized cats and nonanaesthetized, decerebrate cats.
Liang Zhang
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source