Results 181 to 190 of about 202,601 (255)

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

open access: yesArthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu   +11 more
wiley   +1 more source

Expert Perspective: How, When, and Why to Potentially Stop Antiresorptive Drugs in Osteoporosis

open access: yesArthritis &Rheumatology, EarlyView.
Osteoporosis is a chronic disease, and antiresorptive treatments are often continued for many years. Despite their established efficacy in reducing fracture risk, the most commonly used antiresorptive treatments, bisphosphonates and denosumab, have short‐ and long‐term risks that, coupled with their benefits and other unique characteristics, influence ...
Giovanni Adami, Kenneth G. Saag
wiley   +1 more source

Chinese expert consensus on the treatment of modern combat-related spinal injuries. [PDF]

open access: yesMil Med Res, 2019
Zong ZW   +15 more
europepmc   +1 more source

First‐time cefuroxime target tissue concentrations in long‐lasting spine surgery: Continuous evaluation after repeated weight‐dosed administrations

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Antimicrobial prophylaxis is central in preventing postoperative spine infections, yet knowledge on clinical target spine tissue concentrations remain limited. Current dosing regimens often involve fixed doses based on empirical knowledge, surrogate measures, non‐clinical evidence and methodology of variying quality.
Magnus Andreas Hvistendahl   +6 more
wiley   +1 more source

Rigour in interpretive qualitative research in education: Ideas to think with

open access: yesBritish Educational Research Journal, EarlyView.
Abstract There has been a proliferation of qualitative approaches to researching education. While this has resulted in the construction of a rich tapestry of knowledge about education, it has also resulted in disparate research ideas, processes and practices, and created tensions relating to what constitutes rigorous qualitative research in education ...
Anthony J. Maher
wiley   +1 more source

Traumatic spinal injuries in the Kingdom of Saudi Arabia: a study of associated injuries, management and mortality. [PDF]

open access: yesPan Afr Med J, 2019
Alkhathlan KM   +4 more
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

open access: yesBioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

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