Results 201 to 210 of about 745,539 (303)

Analysis of factors influencing the surgical treatment outcomes of spinal injuries in polytrauma patients. [PDF]

Ann Med Surg (Lond)
Sun X, Huang J, Wang W, Gan L, Cao L, Liu Y, Sun S, Wang J, Lu S.   +8 more
europepmc   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Head and Spinal Injuries in Pediatrics: Descriptive Study over 10 Years in a Tertiary Hospital. [PDF]

Cureus
Raffee L, Al Miqdad D, Alawneh K, Negresh N, Al Amaireh R, Al Shatnawi A, Alawneh R, Alawneh H.   +7 more
europepmc   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Cortical reorganization following dorsal spinal injuries in newborn monkeys reveals a critical period in the development of the somatosensory cortex. [PDF]

Proc Natl Acad Sci U S A
Jain N, Qi HX, Raman A, Lyon D, Kaas JH.
europepmc   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Meta-Analysis Investigating Optimal Timing of Chemoprophylaxis for Venous Thromboembolism in Operatively Managed Blunt Spinal Injuries. [PDF]

Int J Spine Surg
AlGhamdi FA, Alzayer MO, AlKabbani MM, AlJoaid RM, AlJoaib NA, Hadhiah KM, AlMaghraby NH.   +6 more
europepmc   +1 more source

Nonmissile penetrating spinal injuries: Mechanisms, expectations, and management. [PDF]

Surg Neurol Int, 2020
Fiani B, Figueras RA, Stefano F, Gautam N, Khan A, Soula M.   +5 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Investigating Research Hotspots of Combat-related Spinal Injuries: A 30-year Bibliometric Analysis Study. [PDF]

Mil Med
Wang P, Zhou S, Li B, Wang Y, Xu W.
europepmc   +1 more source