Results 181 to 190 of about 745,539 (303)

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang   +12 more
wiley   +1 more source

Association of venous thromboembolism following pediatric traumatic spinal injuries with injury severity and longer hospital stays. [PDF]

open access: yesJ Neurosurg Spine, 2022
Hauser BM   +10 more
europepmc   +1 more source

Colonic Emptying after a new Trans Anal Irrigation system in patients with Spinal Cord Injury

open access: yes, 2006
COLONIC EMPTYING AFTER A NEW TRANSANAL IRRIGATION SYSTEM IN PATIENTS WITH SPINAL CORD INJURY Objective: Segmental delays in colonic transit are present and evacuation is incomplete in patients with SCI.
PILLASTRINI, PAOLO   +3 more
core  

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

open access: yesAdvanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang   +4 more
wiley   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan   +10 more
wiley   +1 more source

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