Results 121 to 130 of about 1,138,451 (355)

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

Peyton’s four-step approach for teaching complex spinal manipulation techniques – a prospective randomized trial

BMC Medical Education, 2016
BackgroundThe objectives of this prospective randomized trial were to assess the impact of Peyton’s four-step approach on the acquisition of complex psychomotor skills and to examine the influence of gender on learning outcomes.MethodsWe randomly ...
Gertraud Gradl-Dietsch, Cavan Lübke, K. Horst, M. Simon, A. Modabber, T. Sönmez, Ralf Münker, S. Nebelung, M. Knobe   +8 more
semanticscholar   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Massive hematothorax after thoracic spinal manipulation for acute thoracolumbar pain

Orthopedic Reviews, 2013
Spinal manipulation usually represents a widely used and effective method for physicians in order to relieve acute patient pain and muscular dysbalance. Although life-threatening complications (e.g.
Johannes Struewer, Thomas Manfred Frangen, Ewgeni Ziring, Ulrike Hinterseher, Ilias Kirazidis   +4 more
doaj   +1 more source

Manipulation-induced hypoalgesia in musculoskeletal pain populations: a systematic critical review and meta-analysis

Chiropractic & Manual Therapies, 2019
Background Manipulation-induced hypoalgesia (MIH) represents reduced pain sensitivity following joint manipulation, and has been documented in various populations.
Sasha L. Aspinall, Charlotte Leboeuf-Yde, Sarah J. Etherington, Bruce F. Walker   +3 more
doaj   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

A comparison of spinal manipulation with physical therapy for treatment of patients with mechanical low back pain

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2002
Background and Objective: With regard to high prevalence of mechanical low back pain (LBP) and its increasing in society and known treatment of physical therapy and also previous successes of spinal manipulation, this study was carried out to compare ...
M Rayegani, MH Bahrami, M Farjad, MN Ahrari, N Valaie   +4 more
doaj  

Physiotherapy students\u27 perceptions and experiences of clinical prediction rules [PDF]

, 2016
Objectives: Clinical reasoning can be difficult to teach to pre-professional physiotherapy students due to their lack of clinical experience. It may be that tools such as clinical prediction rules (CPRs) could aid the process, but there has been little ...
Kelly, D, Knox, G, Rivett, D, Snodgrass, S, Stanton, T, Vicenzino, B, Wand, B   +6 more
core   +1 more source

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model

Advanced Science, EarlyView.
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana, Ryan Sentosa, Caterina Sturtzel, Martin Pfister, René Werkmeister, Anna Schmitt, David Traver, Rainer Leitgeb, Wolfgang Drexler, Martin Distel, Angelika Unterhuber   +10 more
wiley   +1 more source

Thoracic spinal thrust manipulation for shoulder impingement syndrome: A meta-analysis of pain relief and functional outcomes

Journal of the Pakistan Medical Association
Objective: To evaluate the effectiveness of thoracic spine thrust manipulation in managing shoulder impingement syndrome. Method: The meta-analysis was conducted from April 25 to November 5, 2023, after approval from the ethics review board of the ...
Bazal Bukhari, Sarwat Ali, Saba Afzal
doaj   +1 more source